DCTN2 (dynactin subunit 2)

2007-02-01 Affiliation

Identity

HGNC

DCTN2

LOCATION

12q13.3

LOCUSID

10540

ALIAS

DCTN50,DYNAMITIN,HEL-S-77,RBP50

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10540
MIM: 607376
HGNC: 2712
Ensembl: ENSG00000175203

Variants:

dbSNP: 10540
ClinVar: 10540
TCGA: ENSG00000175203
COSMIC: DCTN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175203	ENST00000434715	Q13561
ENSG00000175203	ENST00000434715	V9HW58
ENSG00000175203	ENST00000543672	Q13561
ENSG00000175203	ENST00000546670	F8VRV7
ENSG00000175203	ENST00000546758	H0YI98
ENSG00000175203	ENST00000548249	Q13561
ENSG00000175203	ENST00000548249	A0A384MDU9
ENSG00000175203	ENST00000549394	F8W0U6
ENSG00000175203	ENST00000550086	H0YHL1
ENSG00000175203	ENST00000550201	F8W1I6
ENSG00000175203	ENST00000550750	F8VX93
ENSG00000175203	ENST00000550954	F8VW18

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Huntington's disease	KEGG	ko05016
Huntington's disease	KEGG	hsa05016
Vasopressin-regulated water reabsorption	KEGG	ko04962
Vasopressin-regulated water reabsorption	KEGG	hsa04962
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Anchoring of the basal body to the plasma membrane	REACTOME	R-HSA-5620912
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Centrosome maturation	REACTOME	R-HSA-380287
Recruitment of mitotic centrosome proteins and complexes	REACTOME	R-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosome	REACTOME	R-HSA-380284
Loss of Nlp from mitotic centrosomes	REACTOME	R-HSA-380259
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
COPI-mediated anterograde transport	REACTOME	R-HSA-6807878
AURKA Activation by TPX2	REACTOME	R-HSA-8854518
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Golgi-to-ER retrograde transport	REACTOME	R-HSA-8856688
COPI-independent Golgi-to-ER retrograde traffic	REACTOME	R-HSA-6811436

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38842133	2024	Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway.	1
38842133	2024	Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway.	1
34080666	2021	Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells.	2
34080666	2021	Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells.	2
26517670	2016	Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.	7
26517670	2016	Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.	7
25088759	2014	Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5.	7
25088759	2014	Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5.	7
20463029	2010	Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complex.	11
20463029	2010	Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complex.	11
18182012	2008	Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure.	12
18782227	2008	N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.	7
18182012	2008	Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure.	12
18782227	2008	N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.	7
16369996	2006	Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells.	8

Citation

Dessen P

DCTN2 (dynactin subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43939/dctn2-(dynactin-subunit-2)