DCTN2 (dynactin subunit 2)

2007-02-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
DCTN50,DYNAMITIN,HEL-S-77,RBP50
FUSION GENES

Other Information

Locus ID:

NCBI: 10540
MIM: 607376
HGNC: 2712
Ensembl: ENSG00000175203

Variants:

dbSNP: 10540
ClinVar: 10540
TCGA: ENSG00000175203
COSMIC: DCTN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175203ENST00000434715Q13561
ENSG00000175203ENST00000434715V9HW58
ENSG00000175203ENST00000543672Q13561
ENSG00000175203ENST00000546670F8VRV7
ENSG00000175203ENST00000546758H0YI98
ENSG00000175203ENST00000548249Q13561
ENSG00000175203ENST00000548249A0A384MDU9
ENSG00000175203ENST00000549394F8W0U6
ENSG00000175203ENST00000550086H0YHL1
ENSG00000175203ENST00000550201F8W1I6
ENSG00000175203ENST00000550750F8VX93
ENSG00000175203ENST00000550954F8VW18

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Huntington's diseaseKEGGko05016
Huntington's diseaseKEGGhsa05016
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
AURKA Activation by TPX2REACTOMER-HSA-8854518
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
388421332024Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway.1
388421332024Pan-cancer analysis of DCTN2 and its tumour-promoting role in HCC by modulating the AKT pathway.1
340806662021Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells.2
340806662021Binding between ROCK1 and DCTN2 triggers diabetes‑associated centrosome amplification in colon cancer cells.2
265176702016Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.7
265176702016Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family.7
250887592014Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5.7
250887592014Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5.7
204630292010Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complex.11
204630292010Molecular and functional basis for the scaffolding role of the p50/dynamitin subunit of the microtubule-associated dynactin complex.11
181820122008Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure.12
187822272008N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.7
181820122008Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure.12
187822272008N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.7
163699962006Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells.8

Citation

Dessen P

DCTN2 (dynactin subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43939/dctn2-(dynactin-subunit-2)