CXCL9 (C-X-C motif chemokine ligand 9)

2007-02-01  

Identity

HGNC
CXCL9
LOCATION
4q21.1
LOCUSID
4283
ALIAS
CMK,Humig,MIG,SCYB9,crg-10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4283
MIM: 601704
HGNC: 7098
Ensembl: ENSG00000138755

Variants:

dbSNP: 4283
ClinVar: 4283
TCGA: ENSG00000138755
COSMIC: CXCL9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138755ENST00000264888Q07325

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
379378172024The IFN-γ-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment.4
380982302024Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.2
381098642024Association between Circulating Levels of CXCL9 and CXCL10 and Physical Frailty in Older Adults.0
382170232024Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators.2
382291212024CXCL9 may serve as a potential biomarker for primary Sjögren's syndrome with extra-glandular manifestations.1
388223452024Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses.0
389632372024The bioinfomatics analysis of the M1 macrophage-related gene CXCL9 signature in cervical cancer.0
379378172024The IFN-γ-CXCL9/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment.4
380982302024Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.2
381098642024Association between Circulating Levels of CXCL9 and CXCL10 and Physical Frailty in Older Adults.0
382170232024Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicators.2
382291212024CXCL9 may serve as a potential biomarker for primary Sjögren's syndrome with extra-glandular manifestations.1
388223452024Augmentation of tumor expression of HLA-DR, CXCL9, and CXCL10 may improve olfactory neuroblastoma immunotherapeutic responses.0
389632372024The bioinfomatics analysis of the M1 macrophage-related gene CXCL9 signature in cervical cancer.0
363421952023CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment.1

Citation

Dessen P

CXCL9 (C-X-C motif chemokine ligand 9)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43945/cxcl9-(c-x-c-motif-chemokine-ligand-9)