CXCL9 (C-X-C motif chemokine ligand 9)

2007-02-01  

Identity

HGNC
LOCATION
4q21.1
LOCUSID
ALIAS
CMK,Humig,MIG,SCYB9,crg-10
FUSION GENES

Other Information

Locus ID:

NCBI: 4283
MIM: 601704
HGNC: 7098
Ensembl: ENSG00000138755

Variants:

dbSNP: 4283
ClinVar: 4283
TCGA: ENSG00000138755
COSMIC: CXCL9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138755ENST00000264888Q07325

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Toll-like receptor signaling pathwayKEGGko04620
Cytokine-cytokine receptor interactionKEGGhsa04060
Toll-like receptor signaling pathwayKEGGhsa04620
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
151502612004Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function.85
239683322013Multicenter validation of urinary CXCL9 as a risk-stratifying biomarker for kidney transplant injury.60
193447192009Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans.51
201378252010A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B.47
274908022016CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer.47
218129282011Urinary chemokines CXCL9 and CXCL10 are noninvasive markers of renal allograft rejection and BK viral infection.44
194598092009Urinary CXCL9 and CXCL10 levels correlate with the extent of subclinical tubulitis.42
123849332002Involvement of the interferon-gamma-induced T cell-attracting chemokines, interferon-gamma-inducible 10-kd protein (CXCL10) and monokine induced by interferon-gamma (CXCL9), in the salivary gland lesions of patients with Sjögren's syndrome.41
145502882003Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase.39

Citation

Dessen P

CXCL9 (C-X-C motif chemokine ligand 9)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43945/cxcl9-(c-x-c-motif-chemokine-ligand-9)