Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6667
MIM: 189906
HGNC: 11205
Ensembl: ENSG00000185591
Variants:
dbSNP: 6667
ClinVar: 6667
TCGA: ENSG00000185591
COSMIC: SP1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000185591 | ENST00000327443 | P08047 |
| ENSG00000185591 | ENST00000426431 | P08047 |
| ENSG00000185591 | ENST00000548560 | H3BVI2 |
| ENSG00000185591 | ENST00000551969 | H3BUU5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134992438 | CAMK1D | Gene | Pathway | associated | |||
| PA24684 | AKT1 | Gene | Pathway | associated | |||
| PA24685 | AKT2 | Gene | Pathway | associated | |||
| PA24686 | AKT3 | Gene | Pathway | associated | |||
| PA26048 | CAMK1 | Gene | Pathway | associated | |||
| PA26049 | CAMK1G | Gene | Pathway | associated | |||
| PA283 | MAPK8 | Gene | Pathway | associated | |||
| PA30616 | MAPK1 | Gene | Pathway | associated | |||
| PA30622 | MAPK3 | Gene | Pathway | associated | |||
| PA337 | STAT3 | Gene | Pathway | associated | |||
| PA33759 | PRKCA | Gene | Pathway | associated | |||
| PA33761 | PRKCB | Gene | Pathway | associated | |||
| PA33766 | PRKCG | Gene | Pathway | associated | |||
| PA338 | STAT5A | Gene | Pathway | associated | |||
| PA36183 | STAT1 | Gene | Pathway | associated | |||
| PA36184 | STAT2 | Gene | Pathway | associated | |||
| PA36185 | STAT4 | Gene | Pathway | associated | |||
| PA36186 | STAT5B | Gene | Pathway | associated | |||
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation | associated | PK | PD | 24853734 |
| PA443890 | Diabetes Mellitus, Type 2 | Disease | ClinicalAnnotation | associated | PK | PD | 24853734, 29352482 |
| PA450395 | metformin | Chemical | ClinicalAnnotation | associated | PK | PD | 24853734, 29352482 |
| PA90 | CAMK2A | Gene | Pathway | associated | |||
| PA91 | CAMK2B | Gene | Pathway | associated | |||
| PA92 | CAMK2D | Gene | Pathway | associated | |||
| PA93 | CAMK2G | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38159857 | 2024 | KLF6 activates Sp1-mediated prolidase transcription during TGF-β(1) signaling. | 1 |
| 38279869 | 2024 | SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation. | 0 |
| 38286742 | 2024 | Translation regulatory long non-coding RNA 1 negatively regulates cell radiosensitivity via the miR-22-3p/SP1 axis in non-small cell lung cancer. | 1 |
| 38301049 | 2024 | Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification. | 1 |
| 38349188 | 2024 | Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators. | 1 |
| 38368381 | 2024 | RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling. | 0 |
| 38375778 | 2024 | Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1. | 1 |
| 38471646 | 2024 | Three-dimensional chromatin analysis reveals Sp1 as a mediator to program and reprogram HPV-host epigenetic architecture in cervical cancer. | 0 |
| 38533528 | 2024 | Silencing of circ_0088036 inhibits growth and invasion of lung adenocarcinoma through miR-203/SP1 axis. | 0 |
| 38540340 | 2024 | SP1 Gene Methylation in Head and Neck Squamous Cell Cancer in HPV-Negative Patients. | 0 |
| 38572579 | 2024 | hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription. | 0 |
| 38641672 | 2024 | The histone lysine acetyltransferase KAT2B inhibits cholangiocarcinoma growth: evidence for interaction with SP1 to regulate NF2-YAP signaling. | 0 |
| 38840385 | 2024 | GBP1 promotes cutaneous squamous cell carcinoma proliferation and invasion through activation of STAT3 by SP1. | 0 |
| 38940327 | 2024 | SP1‑mediated ADAMTS5 transcription promotes IL‑1β‑induced chondrocyte injury via Wnt/β‑catenin pathway in osteoarthritis. | 0 |
| 38159857 | 2024 | KLF6 activates Sp1-mediated prolidase transcription during TGF-β(1) signaling. | 1 |
Citation
Dessen P
SP1 (Sp1 transcription factor)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43949/sp1-(sp1-transcription-factor)
