Identity
HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
CD295,LEP-R,LEPRD,OB-R,OBR
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3953
MIM: 601007
HGNC: 6554
Ensembl: ENSG00000116678
Variants:
dbSNP: 3953
ClinVar: 3953
TCGA: ENSG00000116678
COSMIC: LEPR
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165108401 | Acute coronary syndrome | Disease | ClinicalAnnotation | associated | PD | 19023160 | |
| PA443797 | Coronary Disease | Disease | ClinicalAnnotation | associated | PD | 18854995 | |
| PA444065 | Epilepsy | Disease | ClinicalAnnotation | associated | PD | ||
| PA444528 | Hyperlipidemias | Disease | ClinicalAnnotation | associated | PD | 14625131 | |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PD | 19023160 | |
| PA451363 | simvastatin | Chemical | ClinicalAnnotation | associated | PD | 14625131, 18854995 | |
| PA451846 | valproic acid | Chemical | ClinicalAnnotation | associated | PD | ||
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD | 21510767 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37801129 | 2024 | Association of polymorphism in leptin receptor gene with susceptibility of adolescent idiopathic scoliosis. | 0 |
| 38091996 | 2024 | Immunomodulatory leptin receptor(+) sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis. | 1 |
| 38275620 | 2024 | Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth. | 0 |
| 38843918 | 2024 | A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers. | 0 |
| 37801129 | 2024 | Association of polymorphism in leptin receptor gene with susceptibility of adolescent idiopathic scoliosis. | 0 |
| 38091996 | 2024 | Immunomodulatory leptin receptor(+) sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis. | 1 |
| 38275620 | 2024 | Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth. | 0 |
| 38843918 | 2024 | A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers. | 0 |
| 36470480 | 2023 | Association of genetic variants in Leptin, leptin receptor and adiponectin with hypertension risk and circulating Leptin/Adiponectin changes. | 1 |
| 36602128 | 2023 | Association of the leptin receptor rs 1805134 polymorphism with obesity parameters, dietary intakes, and metabolic syndrome in Caucasian obese subjects. | 1 |
| 36825860 | 2023 | A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review. | 1 |
| 36864747 | 2023 | Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants. | 1 |
| 36943722 | 2023 | Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis. | 0 |
| 37006245 | 2023 | Deficient leptin receptor signaling in T cells of human SLE. | 0 |
| 37100007 | 2023 | Placenta DNA methylation levels of the promoter region of the leptin receptor gene are associated with infant cortisol. | 2 |
Citation
Dessen P
LEPR (leptin receptor)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43957/lepr-(leptin-receptor)
