Identity
HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
DIAR3,HAI-2,HAI2,Kop,PB
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10653
MIM: 605124
HGNC: 11247
Ensembl: ENSG00000167642
Variants:
dbSNP: 10653
ClinVar: 10653
TCGA: ENSG00000167642
COSMIC: SPINT2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by MST1 | REACTOME | R-HSA-8852405 |
| Signaling by MET | REACTOME | R-HSA-6806834 |
| MET Receptor Activation | REACTOME | R-HSA-6806942 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38271183 | 2024 | SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation. | 0 |
| 38271183 | 2024 | SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation. | 0 |
| 34962618 | 2022 | Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling. | 8 |
| 34962618 | 2022 | Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling. | 8 |
| 33547739 | 2021 | Expansion of the ophthalmic phenotype of SPINT2-related syndromic congenital sodium diarrhea. | 0 |
| 33789993 | 2021 | The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection. | 3 |
| 34089062 | 2021 | Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells. | 2 |
| 34181691 | 2021 | The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. | 3 |
| 34299087 | 2021 | Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction. | 6 |
| 34381422 | 2021 | Comprehensive Analysis of the Expression and Prognostic Value of SPINT1/2 in Breast Carcinoma. | 3 |
| 33547739 | 2021 | Expansion of the ophthalmic phenotype of SPINT2-related syndromic congenital sodium diarrhea. | 0 |
| 33789993 | 2021 | The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection. | 3 |
| 34089062 | 2021 | Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells. | 2 |
| 34181691 | 2021 | The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. | 3 |
| 34299087 | 2021 | Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction. | 6 |
Citation
Dessen P
SPINT2 (serine peptidase inhibitor, Kunitz type 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43960/spint2-(serine-peptidase-inhibitor-kunitz-type-2)
