CYP2A13 (cytochrome P450 family 2 subfamily A member 13)

2007-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
CPAD,CYP2A,CYPIIA13

Other Information

Locus ID:

NCBI: 1553
MIM: 608055
HGNC: 2608
Ensembl: ENSG00000197838

Variants:

dbSNP: 1553
ClinVar: 1553
TCGA: ENSG00000197838
COSMIC: CYP2A13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197838ENST00000330436Q16696

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
XenobioticsREACTOMER-HSA-211981
CYP2E1 reactionsREACTOMER-HSA-211999
Fatty acidsREACTOMER-HSA-211935
Aflatoxin activation and detoxificationREACTOMER-HSA-5423646

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134521193coumarinChemicalVariantAnnotationassociatedPK29342418
PA166181759nnkChemicalVipGeneassociated
PA445876Tobacco Use DisorderDiseaseClinicalAnnotationassociatedPD
PA450626nicotineChemicalClinicalAnnotation, VariantAnnotationassociatedPKPD29342418

References

Pubmed IDYearTitleCitations
146337392003Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.40
146337392003Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.40
174287842007Structure of the human lung cytochrome P450 2A13.33
227009652012Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes.27
197891902009A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.23
121306982002Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.17
121306982002Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.17
186695842008Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.15
193037222009Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.15
214738782011Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.13

Citation

Dessen P

CYP2A13 (cytochrome P450 family 2 subfamily A member 13)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43982/cyp2a13-(cytochrome-p450-family-2-subfamily-a-member-13)