LST1 (leukocyte specific transcript 1)

2007-02-01

Identity

HGNC

LST1

LOCATION

6p21.33

LOCUSID

7940

ALIAS

B144,D6S49E,LST-1

FUSION GENES

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Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7940
MIM: 109170
HGNC: 14189
Ensembl: ENSG00000204482

Variants:

dbSNP: 7940
ClinVar: 7940
TCGA: ENSG00000204482
COSMIC: LST1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204482	ENST00000211921	Q5STB1
ENSG00000204482	ENST00000376090	Q5STB1
ENSG00000204482	ENST00000376099	Q5STB1
ENSG00000204482	ENST00000396101	Q2HNT4
ENSG00000204482	ENST00000396112	F2Z2M1
ENSG00000204482	ENST00000433492	Q5HYT5
ENSG00000204482	ENST00000438075	O00453
ENSG00000204482	ENST00000438075	A0A024RCT6
ENSG00000204482	ENST00000464044	H7C4M3
ENSG00000204482	ENST00000490742	H7C4Z3

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Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443936	Drug Hypersensitivity	Disease	ClinicalAnnotation	associated		PD
PA448004	abacavir	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
22589543	2012	LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.	12
23239025	2013	LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation.	73
23239025	2013	LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation.	73
24682411	2014	Regulated expression of leukocyte-specific transcript (LST) 1 in human intestinal inflammation.	11
24682411	2014	Regulated expression of leukocyte-specific transcript (LST) 1 in human intestinal inflammation.	11
24803336	2014	Identification of functional haplotypes in the promoter region of the LST1 gene.	1
24803336	2014	Identification of functional haplotypes in the promoter region of the LST1 gene.	1
24816991	2014	An upstream open reading frame regulates LST1 expression during monocyte differentiation.	4
24816991	2014	An upstream open reading frame regulates LST1 expression during monocyte differentiation.	4
27384923	2016	Expression of ERAP2 and LST1 is increased before start of therapy in rheumatoid arthritis patients with good clinical response to glucocorticoids.	4

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Citation

Dessen P

LST1 (leukocyte specific transcript 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43983/lst1-(leukocyte-specific-transcript-1)