DDX3X (DEAD-box helicase 3 X-linked)

2007-02-01  

Identity

HGNC
DDX3X
LOCATION
Xp11.4
LOCUSID
1654
ALIAS
CAP-Rf,DBX,DDX14,DDX3,HLP2,MRX102,MRXSSB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1654
MIM: 300160
HGNC: 2745
Ensembl: ENSG00000215301

Variants:

dbSNP: 1654
ClinVar: 1654
TCGA: ENSG00000215301
COSMIC: DDX3X

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000215301ENST00000399959A0A2U3TZJ9
ENSG00000215301ENST00000441189F6S8Q4
ENSG00000215301ENST00000457138O00571
ENSG00000215301ENST00000478993O00571
ENSG00000215301ENST00000542215A0A2R8Y4D2
ENSG00000215301ENST00000611968A0A087WVZ1
ENSG00000215301ENST00000615313A0A2R8YF89
ENSG00000215301ENST00000615742A0A087WX09
ENSG00000215301ENST00000616050A0A0J9YVQ7
ENSG00000215301ENST00000625837A0A0D9SF53
ENSG00000215301ENST00000626301A0A0D9SFB3
ENSG00000215301ENST00000629496O00571
ENSG00000215301ENST00000629785O00571
ENSG00000215301ENST00000630255O00571
ENSG00000215301ENST00000630370A0A0D9SG12
ENSG00000215301ENST00000630858A0A0D9SG12
ENSG00000215301ENST00000642322A0A2R8Y7T2
ENSG00000215301ENST00000642424A0A2R8Y7T2
ENSG00000215301ENST00000642793A0A2R8YCU0
ENSG00000215301ENST00000643821A0A2R8YF31
ENSG00000215301ENST00000643963A0A2R8Y650
ENSG00000215301ENST00000644073A0A2R8YCW1
ENSG00000215301ENST00000644074A0A2R8YFR4
ENSG00000215301ENST00000644109A0A2R8Y645
ENSG00000215301ENST00000644513A0A2R8Y4A4
ENSG00000215301ENST00000644677A0A2R8Y5G6
ENSG00000215301ENST00000644876O00571
ENSG00000215301ENST00000645080A0A2R8YF31
ENSG00000215301ENST00000645589A0A2R8YDH3
ENSG00000215301ENST00000645783A0A2R8YF31
ENSG00000215301ENST00000646107A0A2R8Y5G6
ENSG00000215301ENST00000646122A0A2R8YF78
ENSG00000215301ENST00000646223A0A2R8Y770
ENSG00000215301ENST00000646319A0A2R8YFS5
ENSG00000215301ENST00000646627A0A2R8Y7T2
ENSG00000215301ENST00000646679A0A2R8YDT5
ENSG00000215301ENST00000647373A0A2R8YGJ1

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379046182024Genetic and phenotypic findings in 34 novel Spanish patients with DDX3X neurodevelopmental disorder.0
382182702024A comprehensive review on DDX3X liquid phase condensation in health and neurodevelopmental disorders.0
386643972024NMR characterization of RNA binding property of the DEAD-box RNA helicase DDX3X and its implications for helicase activity.1
386697532024Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone.0
379046182024Genetic and phenotypic findings in 34 novel Spanish patients with DDX3X neurodevelopmental disorder.0
382182702024A comprehensive review on DDX3X liquid phase condensation in health and neurodevelopmental disorders.0
386643972024NMR characterization of RNA binding property of the DEAD-box RNA helicase DDX3X and its implications for helicase activity.1
386697532024Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone.0
365971762023DDX3-mediated miR-34 expression inhibits autophagy and HBV replication in hepatic cells.1
366033052023Inhibition of DDX3X ameliorated CD4(+) T cells pyroptosis and improves survival in septic mice.2
369071122023The involvement of DDX3X in compression-induced nucleus pulposus pyroptosis.0
369828562023Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA.1
371496682023Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.2
373710982023Perturbation Analysis of a Prognostic DDX3X-Mediated Gene Expression Signature Identifies the Antimetastatic Potential of Chaetocin in Hepatocellular Carcinoma.0
378209922023ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21(HRAS) splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade.0

Citation

Dessen P

DDX3X (DEAD-box helicase 3 X-linked)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43986/ddx3x-(dead-box-helicase-3-x-linked)