ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3)

2007-02-01  

Identity

HGNC
ENPP3
LOCATION
6q23.2
LOCUSID
5169
ALIAS
B10,CD203c,NPP3,PD-IBETA,PDNP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5169
MIM: 602182
HGNC: 3358
Ensembl: ENSG00000154269

Variants:

dbSNP: 5169
ClinVar: 5169
TCGA: ENSG00000154269
COSMIC: ENPP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154269ENST00000357639O14638
ENSG00000154269ENST00000358229F8W6H5
ENSG00000154269ENST00000414305O14638
ENSG00000154269ENST00000423831E9PDB4
ENSG00000154269ENST00000427707E7ETI7

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Starch and sucrose metabolismKEGGko00500
Riboflavin metabolismKEGGko00740
Nicotinate and nicotinamide metabolismKEGGko00760
Pantothenate and CoA biosynthesisKEGGko00770
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Starch and sucrose metabolismKEGGhsa00500
Riboflavin metabolismKEGGhsa00740
Nicotinate and nicotinamide metabolismKEGGhsa00760
Pantothenate and CoA biosynthesisKEGGhsa00770
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B5 (pantothenate) metabolismREACTOMER-HSA-199220

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
209752832011Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy.25
201592592010CD203c expression on human basophils is associated with asthma exacerbation.22
172750192007Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy.20
158862252005Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex.18
227226132012Marked differences in the signaling requirements for expression of CD203c and CD11b versus CD63 expression and histamine release in human basophils.10
239600812013Identification of ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) as a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb).9
249475192014Ectonucleotide pyrophosphatase/phosphodiesterase activity in Neuro-2a neuroblastoma cells: changes in expression associated with neuronal differentiation.9
145330062003Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-I beta/B10/gp130RB13-6) in human colon carcinoma.8
150728222004Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases.8

Citation

Dessen P

ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/44005/enpp3-(ectonucleotide-pyrophosphatase-phosphodiesterase-3)