Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4056
MIM: 246530
HGNC: 6719
Ensembl: ENSG00000213316
Variants:
dbSNP: 4056
ClinVar: 4056
TCGA: ENSG00000213316
COSMIC: LTC4S
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000213316 | ENST00000292596 | Q16873 |
| ENSG00000213316 | ENST00000401985 | B5MCC3 |
| ENSG00000213316 | ENST00000486713 | A0A286YF10 |
| ENSG00000213316 | ENST00000505170 | D6RJA1 |
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PD | ||
| PA445999 | Urticaria | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 15100686, 16433794, 19862937 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 15100686, 16433794, 19862937 | |
| PA450546 | montelukast | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34437574 | 2021 | Effect of TGF-β1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease. | 2 |
| 34437574 | 2021 | Effect of TGF-β1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease. | 2 |
| 27365393 | 2016 | Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity. | 5 |
| 27365393 | 2016 | Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity. | 5 |
| 24366866 | 2014 | Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism. | 9 |
| 24366866 | 2014 | Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism. | 9 |
| 23828562 | 2013 | Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes. | 3 |
| 23889244 | 2013 | Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. | 14 |
| 23828562 | 2013 | Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes. | 3 |
| 23889244 | 2013 | Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. | 14 |
| 22217203 | 2012 | Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene C₄ synthase. | 5 |
| 22722751 | 2012 | Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population. | 3 |
| 22884858 | 2012 | The -444A/C polymorphism in the LTC4S gene and the risk of asthma: a meta-analysis. | 8 |
| 23079278 | 2012 | Genetic variation in members of the leukotrienes biosynthesis pathway confers risk of ischemic stroke in Eastern Han Chinese. | 5 |
| 22217203 | 2012 | Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene C₄ synthase. | 5 |
Citation
Dessen P
LTC4S (leukotriene C4 synthase)
Atlas Genet Cytogenet Oncol Haematol. 2007-06-01
Online version: http://atlasgeneticsoncology.org/gene/44018/ltc4s-(leukotriene-c4-synthase)
