TNK2 (tyrosine kinase non receptor 2)

2007-02-01  

Identity

HGNC
LOCATION
3q29
LOCUSID
ALIAS
ACK,ACK-1,ACK1,p21cdc42Hs
FUSION GENES

Other Information

Locus ID:

NCBI: 10188
MIM: 606994
HGNC: 19297
Ensembl: ENSG00000061938

Variants:

dbSNP: 10188
ClinVar: 10188
TCGA: ENSG00000061938
COSMIC: TNK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000061938ENST00000333602Q07912
ENSG00000061938ENST00000381916A0A499FJ16
ENSG00000061938ENST00000428187C9J1X3
ENSG00000061938ENST00000439230Q07912

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174947602007Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.104
174947602007Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.104
162880442005Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.89
162880442005Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.89
162470152005Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.58
203332972010Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.54
167779582006Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli.38
200860932010HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.33
225666992012Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.32
204324602010Shepherding AKT and androgen receptor by Ack1 tyrosine kinase.30

Citation

Dessen P

TNK2 (tyrosine kinase non receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/44030/tnk2-(tyrosine-kinase-non-receptor-2)