MIB2 (mindbomb homolog 2 (Drosophila))
2008-01-01 Tamotsu Takeuchi AffiliationDepartment of Pathology, Kochi Medical School, Kohasu, Okou, Nankoku, Kochi 783 8505, Japan
DNA/RNA
Note
There are at least six alternative splicing forms.
Genomic structure of Mib2/skeletrophin
Description
20 Exons spanning 14kb on 1p36.33.
Proteins
Note
The number of amino acids are varied in each splicing form.
Schematic illustrating of mib2/skeletrophin.
Expression
Human mib2/skeletrophin is strongly expressed in adult brain, heart and skeletal muscles.
Localisation
Cytoplasmic
Function
Ubiquitin ligase to cytoplasmic domain of Notch ligands and NMDA receptor GRIN2B/NR2B subunit. Putative positive regulation of I-kappaB kinase/NF-kappaB cascade.
Homology
The protein structure of mib2/skeletrophin is closely related to MIB1 (mind bomb-1 homolog).
Implicated in
Entity name
Multiple myeloma, especially at advanced stage with osteolytic lesion.
Oncogenesis
Putative oncogenic factor for multiple myeloma thorough bone marrow microenvironments. In multiple myeloma, Mib2/skeletrophin and its substrates, Jagged-1 and Jagged-2, are both overexpressed in bone marrow microenvironments. Ligands-dependent Notch activation is occurred by direct cell-cell interaction between multiple myeloma cells and bone marrow stromal cells and contribute the myeloma niche, which is known as microenvironment suitable for myelomagenesis.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 17962190 | 2008 | Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. | Jurd R et al |
| 15824097 | 2005 | Mind bomb-2 is an E3 ligase for Notch ligand. | Koo BK et al |
| 16715130 | 2006 | A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. | Takeuchi T et al |
Other Information
Locus ID:
NCBI: 142678
MIM: 611141
HGNC: 30577
Ensembl: ENSG00000197530
Variants:
dbSNP: 142678
ClinVar: 142678
TCGA: ENSG00000197530
COSMIC: MIB2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37436668 | 2023 | MIB2 promotes the progression of non-small cell lung cancer by regulating cell cycle control pathways. | 0 |
| 37436668 | 2023 | MIB2 promotes the progression of non-small cell lung cancer by regulating cell cycle control pathways. | 0 |
| 34971948 | 2022 | E3 ubiquitin-protein ligase 2 inhibits cell proliferation, migration, and invasion of non-small cell lung cancer through ubiquitination of Notch1. | 2 |
| 34971948 | 2022 | E3 ubiquitin-protein ligase 2 inhibits cell proliferation, migration, and invasion of non-small cell lung cancer through ubiquitination of Notch1. | 2 |
| 33469115 | 2021 | MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L). | 8 |
| 33469115 | 2021 | MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L). | 8 |
| 31366726 | 2019 | The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. | 14 |
| 31366726 | 2019 | The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. | 14 |
| 29642005 | 2018 | Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. | 29 |
| 29642005 | 2018 | Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. | 29 |
| 28013292 | 2017 | MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy. | 4 |
| 28013292 | 2017 | MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy. | 4 |
| 25142606 | 2014 | Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein. | 28 |
| 25565632 | 2014 | The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling. | 13 |
| 25142606 | 2014 | Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein. | 28 |
Citation
Tamotsu Takeuchi
MIB2 (mindbomb homolog 2 (Drosophila))
Atlas Genet Cytogenet Oncol Haematol. 2008-01-01
Online version: http://atlasgeneticsoncology.org/gene/44179/mib2-(mindbomb-homolog-2-(drosophila))
