ANLN (anillin, actin binding protein)
2009-01-01 Yataro Daigo , Yusuke Nakamura AffiliationLaboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Identity
HGNC
LOCATION
7p14.2
LOCUSID
ALIAS
FSGS8,Scraps,scra
FUSION GENES
DNA/RNA
Description
The ANLN gene consists of 63,969 bases and at least 23 exons.
Transcription
The transcribed mRNA is 4,786 bp.
Proteins
Description
The human ANLN cDNA encodes a protein (1124 amino acids; 124199 Da) that includes an actin-binding domain and a C-terminal domain with pleckstrin homology (PH). It also contains several consensus nuclear localization sequences (NLS) and one consensus SH3-binding motif.
Expression
ANLN is mainly expressed in adult placenta, testis, and spinal cord, and in fetal organs (brain, heart, kidney, liver, lung, skeletal muscle, spleen and thymus).
Localisation
ANLN is mainly found in nucleus, cytoplasm, cytoskeleton, cleavage furrow, and cell cortex.
Function
Anillin (ANLN) was initially characterized as a human homologue of anillin, a Drosophila actin-binding protein. ANLN localizes not only to the cytoplasm but also to nuclei in some proportion of cancer cells; it is likely to present at the cortex following breakdown of the nuclear envelope, and in the cleavage furrow during cytokinesis. ANLN plays an important role in cell-cycle progression. In late phases ANLN may assemble the actin and myosin contractile ring that separates daughter cells, through interaction with at least two other furrow proteins, actin and septins (SEPTs). ANLN is supposed to be a substrate of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that controls mitotic progression.
Implicated in
Entity name
Lung cancer
Prognosis
Nuclear ANLN (n-ANLN) was indicated to be an independent prognostic factor for patients with non-small cell lung cancer.
Oncogenesis
ANLN interacts with and activates RHOA, and this complex is likely to be essential for the growth-promoting pathway and aggressive features of lung cancers as well as for cell division. Moreover n-ANLN whose nuclear localization and stability are regulated by PI3K/ AKT signaling, appears to regulate the malignant potential of cancer cells.
Entity name
Prostate cancer
Note
Overexpression of ANLN was observed in hormone-refractory prostate cancers (HRPCs)
Entity name
Head and neck squamous cell carcinoma
Note
Overexpression of ANLN was observed in head and neck squamous cell carcinomas (HNSCCs).
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 16203764 | 2005 | The septin-binding protein anillin is overexpressed in diverse human tumors. | Hall PA et al |
| 17982635 | 2007 | Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. | Shimizu S et al |
| 16357138 | 2005 | ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. | Suzuki C et al |
| 17545589 | 2007 | Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles. | Tamura K et al |
Other Information
Locus ID:
NCBI: 54443
MIM: 616027
HGNC: 14082
Ensembl: ENSG00000011426
Variants:
dbSNP: 54443
ClinVar: 54443
TCGA: ENSG00000011426
COSMIC: ANLN
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35504258 | 2023 | ANLN Serves as an Oncogene in Bladder Urothelial Carcinoma via Activating JNK Signaling Pathway. | 5 |
| 36894036 | 2023 | A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23. | 6 |
| 37539739 | 2023 | Knockdown of ANLN inhibits the progression of lung adenocarcinoma via pyroptosis activation. | 4 |
| 37957688 | 2023 | Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism. | 2 |
| 35504258 | 2023 | ANLN Serves as an Oncogene in Bladder Urothelial Carcinoma via Activating JNK Signaling Pathway. | 5 |
| 36894036 | 2023 | A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23. | 6 |
| 37539739 | 2023 | Knockdown of ANLN inhibits the progression of lung adenocarcinoma via pyroptosis activation. | 4 |
| 37957688 | 2023 | Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism. | 2 |
| 35340220 | 2022 | Comprehensive Analysis of ANLN in Human Tumors: A Prognostic Biomarker Associated with Cancer Immunity. | 4 |
| 35924788 | 2022 | E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA-383-5p transcription. | 3 |
| 36416720 | 2022 | Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA. | 2 |
| 35340220 | 2022 | Comprehensive Analysis of ANLN in Human Tumors: A Prognostic Biomarker Associated with Cancer Immunity. | 4 |
| 35924788 | 2022 | E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA-383-5p transcription. | 3 |
| 36416720 | 2022 | Cytokinetic diversity in mammalian cells is revealed by the characterization of endogenous anillin, Ect2 and RhoA. | 2 |
| 32880660 | 2021 | Anillin is an emerging regulator of tumorigenesis, acting as a cortical cytoskeletal scaffold and a nuclear modulator of cancer cell differentiation. | 20 |
Citation
Yataro Daigo ; Yusuke Nakamura
ANLN (anillin, actin binding protein)
Atlas Genet Cytogenet Oncol Haematol. 2009-01-01
Online version: http://atlasgeneticsoncology.org/gene/44318/anln-(anillin-actin-binding-protein)
