FSCN1 (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))
2008-11-01 Shoichi Nagai , Christian A Smith , Soma Mondal , James T Rutka AffiliationThe Arthur, Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Identity
HGNC
LOCATION
7p22.1
LOCUSID
ALIAS
FAN1,HSN,SNL,p55
FUSION GENES
DNA/RNA
Description
The gene encompasses 13,833 bp of DNA.
Transcription
The length of the transcript is 2,819 bp containing 1,482 bp open reading frame.
Proteins
Description
FSCN1 encodes a 493-amino acid protein fascin with a molecular mass of 55 kD. Fascin was first isolated from sea urchin egg extracts, and then identified in Drosophila and in B-lymphocytes.
Expression
Fascin is widely expressed including the brain, blood, colon, lung, breast, ovary, and testis. In the brain, fascin expression has been localized to neurons, glial cells, and endothelial cells.
Localisation
Fascin colocalizes with filopodia, membrane ruffles, lamellopodia, microspikes, focal adhesions, cytoplasm and actin stress fibers. Additionally, fascin has been shown to localize to lamellipodia and filopodia in growth cones of cultured neurons.
Function
Fascin is an actin-bundling protein that provides rigidity to filopodial bundles to efficiently push the membrane forward during cytoskeleton remodeling and cell migration.
Mutations
Germinal
unknown
Somatic
unknown
Implicated in
Entity name
Glioma
Disease
Fascin expression increases with increasing histological grade of glioma and is associated with adhesion, migration, and invasion of glioma cells.
Entity name
Cancer
Disease
High-level expression of fascin has been observed in several types of human neoplasms, such as cancer of colon, breast, lung, kidney, ovary, cervix, and esophagus. It correlates with lymph node or distant metastasis in cancers of colon, kidney, and esophagus, and plays a role as an independent marker of poor prognosis. It is also associated with increased cellular proliferation in non-small cell lung adenocarcinoma, colon carcinoma, and esophageal squamous cell carcinoma. In colon adenocarcinoma and esophageal carcinoma cells, fascin is associated with cellular motility and invasive properties.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 17650213 | 2007 | Expression of fascin in oral and oropharyngeal squamous cell carcinomas has prognostic significance - a tissue microarray study of 129 cases. | Chen SF et al |
| 11039904 | 2000 | C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines. | Grothey A et al |
| 17029629 | 2006 | Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas. | Hashimoto Y et al |
| 18283337 | 2008 | The role of fascin in the migration and invasiveness of malignant glioma cells. | Hwang JH et al |
| 12507891 | 2003 | Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro. | Jawhari AU et al |
| 16620052 | 2006 | Actin bundling protein fascin expression in ovarian neoplasms: comparison of histopathologic features of tumors obtained by the first and secondary cytoreduction surgeries. | Kabukcuoglu S et al |
| 12592367 | 2003 | Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer. | Pelosi G et al |
| 14756441 | 2003 | Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades. | Peraud A et al |
| 17375048 | 2007 | Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma. | Puppa G et al |
| 16308158 | 2005 | Fascin expression in 90 patients with glioblastoma multiforme. | Roma AA et al |
| 16185662 | 2005 | Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells. | Xie JJ et al |
| 16524962 | 2006 | Fascin is a potential biomarker for early-stage oesophageal squamous cell carcinoma. | Zhang H et al |
| 16979727 | 2006 | Biologic significance of fascin expression in clear cell renal cell carcinoma: systematic analysis of primary and metastatic tumor tissues using a tissue microarray technique. | Zigeuner R et al |
Other Information
Locus ID:
NCBI: 6624
MIM: 602689
HGNC: 11148
Ensembl: ENSG00000075618
Variants:
dbSNP: 6624
ClinVar: 6624
TCGA: ENSG00000075618
COSMIC: FSCN1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37981069 | 2024 | CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing. | 1 |
| 38411274 | 2024 | KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma. | 0 |
| 38449390 | 2024 | SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy. | 1 |
| 38587571 | 2024 | The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women. | 0 |
| 38679464 | 2024 | N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma. | 0 |
| 38964493 | 2024 | The FSCN1 gene rs2966447 variant is associated with increased serum fascin-1 levels and breast cancer susceptibility. | 0 |
| 37981069 | 2024 | CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing. | 1 |
| 38411274 | 2024 | KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma. | 0 |
| 38449390 | 2024 | SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy. | 1 |
| 38587571 | 2024 | The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women. | 0 |
| 38679464 | 2024 | N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma. | 0 |
| 38964493 | 2024 | The FSCN1 gene rs2966447 variant is associated with increased serum fascin-1 levels and breast cancer susceptibility. | 0 |
| 36927659 | 2023 | The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression. | 2 |
| 36971100 | 2023 | FSCN1 as a new druggable target in adrenocortical carcinoma. | 3 |
| 37147713 | 2023 | SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion. | 1 |
Citation
Shoichi Nagai ; Christian A Smith ; Soma Mondal ; James T Rutka
FSCN1 (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))
Atlas Genet Cytogenet Oncol Haematol. 2008-11-01
Online version: http://atlasgeneticsoncology.org/gene/44342/fscn1-(fascin-homolog-1-actin-bundling-protein-(strongylocentrotus-purpuratus))
