BOP1 (block of proliferation 1)
2008-10-01 Audrey Killian , Richard Sesboüé AffiliationINSERM U614, Faculté de Médecine-Pharmacie de Rouen, 22 boulevard Gambetta, 76183 ROUEN Cedex 1, France
DNA/RNA
A: Genomic structure of BOP1: the gene extends over 29kb with 16 exons (lower part). Exons 4-16 (upper part) are clustered in 2.6 kb while exons 1-3 are separated by large (2-12 kb) introns.
Description
The BOP1 gene is situated 16.6 Mb downstream from the MYC proto-oncogene (8q24.21) and 0.8 Mb upstream from the telomere (Fig1B).
Transcription
BOP1 mRNA (NM_015201) has a size of 2422 bp.
Pseudogene
No pseudogene has been reported for BOP1, but the NCBI Map viewer (Build 36.3) displays a perfect match encompassing exons 4-16, 64kb centromeric to the gene.
Proteins
Position of the WD repeats.
Description
The Ribosome biogenesis protein BOP1 consists of 746 amino acids and has a molecular weight of 83.63 kDa. It contains 7 WD repeats.
Expression
BOP1 is expressed ubiquitously and found in nearly all tissues at similar levels.
Localisation
Nucleus, nucleolus.
Function
Required for maturation of the 25S and 5.8S ribosomal RNAs. Essential for cell proliferation. Involved in chromosomal segregation.
Homology
Mus musculus Bop1; Rattus norvegicus Bop1; Equus caballus BOP1; Bos taurus BOP1
Mutations
Note
None described to date.
Implicated in
Entity name
Colorectal cancer
Note
A copy number increase of the BOP1 gene was detected in 39% of colorectal cancer samples (n=56) and was associated with an increase of its mRNA level. This copy number increase was more frequent than that observed for MYC, a proto-oncogene located 16.6 Mb upstream from BOP1 and was distinct from MYC amplification in 16% of the cases.
Transient overexpression of BOP1 in human cells increased the percentage of abnormal mitoses with multipolar spindles.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 16738141 | 2006 | Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. | Grimm T et al |
| 16043514 | 2005 | Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. | Hölzel M et al |
| 15467761 | 2004 | Inactivation of the RRB1-Pescadillo pathway involved in ribosome biogenesis induces chromosomal instability. | Killian A et al |
| 16804918 | 2006 | Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis. | Killian A et al |
| 17353269 | 2007 | Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. | Rohrmoser M et al |
Other Information
Locus ID:
NCBI: 23246
MIM: 610596
HGNC: 15519
Ensembl: ENSG00000261236
Variants:
dbSNP: 23246
ClinVar: 23246
TCGA: ENSG00000261236
COSMIC: BOP1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000261236 | ENST00000569403 | A0A075B729 |
| ENSG00000261236 | ENST00000569669 | Q14137 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37615370 | 2023 | PDGF-C promotes cell proliferation partially via downregulating BOP1. | 0 |
| 37681336 | 2023 | BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway. | 0 |
| 37615370 | 2023 | PDGF-C promotes cell proliferation partially via downregulating BOP1. | 0 |
| 37681336 | 2023 | BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway. | 0 |
| 33039351 | 2021 | Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression. | 6 |
| 33510838 | 2021 | BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis. | 5 |
| 33797754 | 2021 | BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated β-catenin acetylation. | 14 |
| 33877544 | 2021 | BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation. | 4 |
| 33039351 | 2021 | Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression. | 6 |
| 33510838 | 2021 | BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis. | 5 |
| 33797754 | 2021 | BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated β-catenin acetylation. | 14 |
| 33877544 | 2021 | BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation. | 4 |
| 32167616 | 2020 | Block of proliferation 1 promotes cell migration and invasion in human colorectal cancer cells via the JNK pathway. | 7 |
| 32805281 | 2020 | The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. | 55 |
| 32167616 | 2020 | Block of proliferation 1 promotes cell migration and invasion in human colorectal cancer cells via the JNK pathway. | 7 |
Citation
Audrey Killian ; Richard Sesboüé
BOP1 (block of proliferation 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-10-01
Online version: http://atlasgeneticsoncology.org/gene/44348/bop1-(block-of-proliferation-1)
