TYK2 (tyrosine kinase 2)

2003-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
IMD35,JTK1
FUSION GENES

Other Information

Locus ID:

NCBI: 7297
MIM: 176941
HGNC: 12440
Ensembl: ENSG00000105397

Variants:

dbSNP: 7297
ClinVar: 7297
TCGA: ENSG00000105397
COSMIC: TYK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105397ENST00000264818P29597
ENSG00000105397ENST00000264818A0A024R7E4
ENSG00000105397ENST00000524462E9PM19
ENSG00000105397ENST00000525220H0YE41
ENSG00000105397ENST00000525621P29597
ENSG00000105397ENST00000525621A0A024R7E4
ENSG00000105397ENST00000525976H0YE24
ENSG00000105397ENST00000527481K7EM33
ENSG00000105397ENST00000529370E9PPF2
ENSG00000105397ENST00000530560K7EJR6
ENSG00000105397ENST00000530829E9PQE9
ENSG00000105397ENST00000531836E9PQL2
ENSG00000105397ENST00000533334H0YCT7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Regulation of IFNA signalingREACTOMER-HSA-912694
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 signalingREACTOMER-HSA-1059683
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
RAF-independent MAPK1/3 activationREACTOMER-HSA-112409
MAPK3 (ERK1) activationREACTOMER-HSA-110056
MAPK1 (ERK2) activationREACTOMER-HSA-112411
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379504072024Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.0
383371612024Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population.1
379504072024Community analysis of large-scale molecular dynamics simulations elucidated dynamics-driven allostery in tyrosine kinase 2.0
383371612024Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population.1
365196212023Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.6
367815022023The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.0
368348062023Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.17
369594162023TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.2
378608322023Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.1
379832652023Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2.3
365196212023Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway.6
367815022023The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.0
368348062023Tyk2 Targeting in Immune-Mediated Inflammatory Diseases.17
369594162023TYK2 single-nucleotide variants associated with the severity of COVID-19 disease.2
378608322023Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2.1

Citation

Dessen P

TYK2 (tyrosine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/446/js/deep-insight-explorer/hgnc