PRMT5 (protein arginine methyltransferase 5)

2007-02-01  

Identity

HGNC
PRMT5
LOCATION
14q11.2
LOCUSID
10419
ALIAS
HRMT1L5,HSL7,IBP72,JBP1,SKB1,SKB1Hs
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10419
MIM: 604045
HGNC: 10894
Ensembl: ENSG00000100462

Variants:

dbSNP: 10419
ClinVar: 10419
TCGA: ENSG00000100462
COSMIC: PRMT5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100462ENST00000216350O14744
ENSG00000100462ENST00000324366O14744
ENSG00000100462ENST00000397440O14744
ENSG00000100462ENST00000397441O14744
ENSG00000100462ENST00000421938C9JSX3
ENSG00000100462ENST00000454731H7BZ44
ENSG00000100462ENST00000553502H0YJ77
ENSG00000100462ENST00000553550G3V2L6
ENSG00000100462ENST00000553787G3V507
ENSG00000100462ENST00000553897O14744
ENSG00000100462ENST00000553915G3V3A3
ENSG00000100462ENST00000554867G3V580
ENSG00000100462ENST00000554910G3V5L5
ENSG00000100462ENST00000555454H0YJD3
ENSG00000100462ENST00000555530H0YJX6
ENSG00000100462ENST00000556043G3V5T6
ENSG00000100462ENST00000556616G3V2X6
ENSG00000100462ENST00000557415G3V2F5
ENSG00000100462ENST00000557443H0YJY6
ENSG00000100462ENST00000627278G3V507

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Metabolism of non-coding RNAREACTOMER-HSA-194441
snRNP AssemblyREACTOMER-HSA-191859
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through MethylationREACTOMER-HSA-6804760

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379632002024CircMMP2(6,7) Cooperates with β-Catenin and PRMT5 to Disrupt Bone Homeostasis and Promote Breast Cancer Bone Metastasis.1
381056192024Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex.1
382526632024Brg1/PRMT5 nuclear complex epigenetically regulates FOXO1 in IPF mesenchymal progenitor cells.0
382728552024ETD-Based Proteomic Profiling Improves Arginine Methylation Identification and Reveals Novel PRMT5 Substrates.0
384382512024SMYD4 monomethylates PRMT5 and forms a positive feedback loop to promote hepatocellular carcinoma progression.2
384740892024Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2(low) Adult T-Cell Leukemia/Lymphoma.0
386261792024CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.0
386639412024Identification of protein methyltransferases 5 associated with ferroptosis and immune cell infiltration of head and neck squamous cell carcinoma.0
379632002024CircMMP2(6,7) Cooperates with β-Catenin and PRMT5 to Disrupt Bone Homeostasis and Promote Breast Cancer Bone Metastasis.1
381056192024Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex.1
382526632024Brg1/PRMT5 nuclear complex epigenetically regulates FOXO1 in IPF mesenchymal progenitor cells.0
382728552024ETD-Based Proteomic Profiling Improves Arginine Methylation Identification and Reveals Novel PRMT5 Substrates.0
384382512024SMYD4 monomethylates PRMT5 and forms a positive feedback loop to promote hepatocellular carcinoma progression.2
384740892024Inhibition of PRMT5/MEP50 Arginine Methyltransferase Activity Causes Cancer Vulnerability in NDRG2(low) Adult T-Cell Leukemia/Lymphoma.0
386261792024CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.0

Citation

Dessen P

PRMT5 (protein arginine methyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45521/prmt5-(protein-arginine-methyltransferase-5)