KIF20A (kinesin family member 20A)

2007-02-01  

Identity

HGNC
KIF20A
LOCATION
5q31.2
LOCUSID
10112
ALIAS
MKLP2,RAB6KIFL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10112
MIM: 605664
HGNC: 9787
Ensembl: ENSG00000112984

Variants:

dbSNP: 10112
ClinVar: 10112
TCGA: ENSG00000112984
COSMIC: KIF20A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112984ENST00000394894O95235
ENSG00000112984ENST00000502338H0YAC9
ENSG00000112984ENST00000504621D6RBN1
ENSG00000112984ENST00000508792O95235
ENSG00000112984ENST00000513276D6R9E4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380378342024KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1α Axis.0
380378342024KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1α Axis.0
366379532023High expression of KIF20A in bladder cancer as a potential prognostic target for poor survival of renal cell carcinoma.4
367632212023Circ_0084188 Regulates the progression of colorectal cancer through the miR-769-5p/KIF20A axis.0
372483202023Grade scoring system reveals distinct molecular subtypes and identifies KIF20A as a novel biomarker for predicting temozolomide treatment efficiency in gliomas.0
366379532023High expression of KIF20A in bladder cancer as a potential prognostic target for poor survival of renal cell carcinoma.4
367632212023Circ_0084188 Regulates the progression of colorectal cancer through the miR-769-5p/KIF20A axis.0
372483202023Grade scoring system reveals distinct molecular subtypes and identifies KIF20A as a novel biomarker for predicting temozolomide treatment efficiency in gliomas.0
354186892022The kinesin KIF20A promotes progression to castration-resistant prostate cancer through autocrine activation of the androgen receptor.10
356385752022MKLP2 functions in early mitosis to ensure proper chromosome congression.4
360379252022KIF20A promotes the development of fibrosarcoma via PI3K-Akt signaling pathway.3
354186892022The kinesin KIF20A promotes progression to castration-resistant prostate cancer through autocrine activation of the androgen receptor.10
356385752022MKLP2 functions in early mitosis to ensure proper chromosome congression.4
360379252022KIF20A promotes the development of fibrosarcoma via PI3K-Akt signaling pathway.3
336861652021The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.9

Citation

Dessen P

KIF20A (kinesin family member 20A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45523/meetings/gene-fusions/humanGenome