Identity
HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN-II,PN2,alpha-sAPP,preA4
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 351
MIM: 104760
HGNC: 620
Ensembl: ENSG00000142192
Variants:
dbSNP: 351
ClinVar: 351
TCGA: ENSG00000142192
COSMIC: APP
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37307834 | 2024 | Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease. | 6 |
| 37558161 | 2024 | Physical activity and amyloid beta in middle-aged and older adults: A systematic review and meta-analysis. | 2 |
| 37633469 | 2024 | Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease. | 0 |
| 37652560 | 2024 | The molecular spectrum of amyloid-beta (Aβ) in neurodegenerative diseases beyond Alzheimer's disease. | 3 |
| 37679610 | 2024 | Capillary dysfunction in healthy elderly APOE ε4 carriers with raised brain Aβ deposition. | 0 |
| 37801139 | 2024 | Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease. | 3 |
| 37820938 | 2024 | Arrangement of lipid vesicles and bicelle-like structures formed in the presence of Aβ(25-35) peptide. | 0 |
| 37879623 | 2024 | Associations Between Blood Nutritional Biomarkers and Cerebral Amyloid-β: Insights From the COGFRAIL Cohort Study. | 0 |
| 38013121 | 2024 | GDP dissociation inhibitor 1 (GDI1) attenuates β-amyloid-induced neurotoxicity in Alzheimer's diseases. | 0 |
| 38086389 | 2024 | APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread. | 9 |
| 38103630 | 2024 | Age of onset predicted by Aβ profiling in a novel PSEN1 (I180F) mutation. | 0 |
| 38123362 | 2024 | Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. | 0 |
| 38211684 | 2024 | Potential links between platelets and amyloid-β in the pathogenesis of Alzheimer's disease: Evidence from in vitro, in vivo, and clinical studies. | 0 |
| 38217596 | 2024 | Interaction Between Arteriosclerosis and Amyloid-β on Cognitive Function. | 0 |
| 38244652 | 2024 | Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms. | 0 |
Citation
Dessen P
APP (amyloid beta precursor protein)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45541/app
