Identity
HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
PAD,PAD4,PADI5,PDI4,PDI5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23569
MIM: 605347
HGNC: 18368
Ensembl: ENSG00000159339
Variants:
dbSNP: 23569
ClinVar: 23569
TCGA: ENSG00000159339
COSMIC: PADI4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000159339 | ENST00000375448 | Q9UM07 |
| ENSG00000159339 | ENST00000375453 | B1AQ67 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166178378 | uric acid | Chemical | VariantAnnotation | associated | PK | 29580174 | |
| PA444552 | Hypertension | Disease | VariantAnnotation | associated | PK | 29580174 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37751115 | 2024 | Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani Population. | 0 |
| 38151017 | 2024 | hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50. | 3 |
| 37751115 | 2024 | Polymorphic Analysis of Genes PADI4 (rs2240340, rs1748033) and HLA-DRB1 (rs2395175) in Arthritis Patients in Pakistani Population. | 0 |
| 38151017 | 2024 | hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50. | 3 |
| 35702765 | 2023 | The Role of Peptidyl Arginine Deiminase IV(PADI4) in Cancers. | 1 |
| 36372391 | 2023 | The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4. | 2 |
| 36535460 | 2023 | A common missense variant rs874881 of PADI4 gene and rheumatoid arthritis: Genetic association study and in-silico analysis. | 1 |
| 36961884 | 2023 | Neutrophil PAD4: how does it function in cancer beyond promoting NETosis? | 1 |
| 37140445 | 2023 | An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression. | 5 |
| 37145011 | 2023 | PADI4 and IL-33 gene polymorphisms with susceptibility to systemic lupus erythematosus and juvenile idiopathic arthritis, a systematic review and meta-analysis. | 0 |
| 37193992 | 2023 | Implications of Peptidyl Arginine Deiminase 4 gene transcription and polymorphisms in susceptibility to rheumatoid arthritis in an Iranian population. | 1 |
| 37409874 | 2023 | New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4. | 3 |
| 37759458 | 2023 | Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients. | 2 |
| 35702765 | 2023 | The Role of Peptidyl Arginine Deiminase IV(PADI4) in Cancers. | 1 |
| 36372391 | 2023 | The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4. | 2 |
Citation
Dessen P
PADI4 (peptidyl arginine deiminase 4)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45545/padi4-(peptidyl-arginine-deiminase-4)
