PADI4 (peptidyl arginine deiminase 4)

2007-02-01  

Identity

HGNC
LOCATION
1p36.13
LOCUSID
ALIAS
PAD,PAD4,PADI5,PDI4,PDI5
FUSION GENES

Other Information

Locus ID:

NCBI: 23569
MIM: 605347
HGNC: 18368
Ensembl: ENSG00000159339

Variants:

dbSNP: 23569
ClinVar: 23569
TCGA: ENSG00000159339
COSMIC: PADI4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159339ENST00000375448Q9UM07
ENSG00000159339ENST00000375453B1AQ67

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166178378uric acidChemicalVariantAnnotationassociatedPK29580174
PA444552HypertensionDiseaseVariantAnnotationassociatedPK29580174

References

Pubmed IDYearTitleCitations
153457772004Human PAD4 regulates histone arginine methylation levels via demethylimination.288
128331572003Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.236
163809152005Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.166
163809152005Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.166
123938682002Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes.114
179689292007Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation.112
152479072004Structural basis for Ca(2+)-induced activation of human PAD4.109
185058182008Regulation of p53 target gene expression by peptidylarginine deiminase 4.94
160606662005Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis.77
186685622008Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis.73

Citation

Dessen P

PADI4 (peptidyl arginine deiminase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45545/padi4-(peptidyl-arginine-deiminase-4)