PEX5 (peroxisomal biogenesis factor 5)

2007-02-01 Affiliation

Identity

HGNC

PEX5

LOCATION

12p13.31

LOCUSID

5830

ALIAS

PBD2A,PBD2B,PTS1-BP,PTS1R,PXR1,RCDP5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5830
MIM: 600414
HGNC: 9719
Ensembl: ENSG00000139197

Variants:

dbSNP: 5830
ClinVar: 5830
TCGA: ENSG00000139197
COSMIC: PEX5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000139197	ENST00000266563	P50542
ENSG00000139197	ENST00000266563	A0A0S2Z4F3
ENSG00000139197	ENST00000266564	P50542
ENSG00000139197	ENST00000266564	A0A0S2Z480
ENSG00000139197	ENST00000396637	J3KPV0
ENSG00000139197	ENST00000412720	B4E0T2
ENSG00000139197	ENST00000420616	P50542
ENSG00000139197	ENST00000420616	A0A0S2Z4H1
ENSG00000139197	ENST00000434354	P50542
ENSG00000139197	ENST00000455147	P50542
ENSG00000139197	ENST00000455147	A0A0S2Z4H1
ENSG00000139197	ENST00000536841	F5H205
ENSG00000139197	ENST00000536883	F5GZ41
ENSG00000139197	ENST00000537873	F5H637
ENSG00000139197	ENST00000540398	F5H432
ENSG00000139197	ENST00000541850	H0YGT8
ENSG00000139197	ENST00000542539	F5H3X7
ENSG00000139197	ENST00000543974	F5H0L9
ENSG00000139197	ENST00000544456	F5GXX3
ENSG00000139197	ENST00000545574	F5H5C0
ENSG00000139197	ENST00000545845	F5GYB4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Peroxisome	KEGG	ko04146
Peroxisome	KEGG	hsa04146

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26344566	2015	ATM functions at the peroxisome to induce pexophagy in response to ROS.	99
16314507	2005	Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.	54
17317787	2007	Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure.	54
18359941	2008	Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor.	33
22371489	2012	Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.	31
21976670	2011	PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.	29
16403517	2006	The N-terminal half of the peroxisomal cycling receptor Pex5p is a natively unfolded domain.	25
19208625	2009	Properties of the ubiquitin-pex5p thiol ester conjugate.	25
12411433	2003	Characterization of the peroxisomal cycling receptor, Pex5p, using a cell-free in vitro import system.	23
19632994	2009	Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway.	20

Citation

Dessen P

PEX5 (peroxisomal biogenesis factor 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45552/pex5-(peroxisomal-biogenesis-factor-5)