SLC5A3 (solute carrier family 5 member 3)

2007-02-01

Identity

HGNC

SLC5A3

LOCATION

21q22.11

LOCUSID

6526

ALIAS

BCW2,SMIT,SMIT1,SMIT2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6526
MIM: 600444
HGNC: 11038
Ensembl: ENSG00000198743

Variants:

dbSNP: 6526
ClinVar: 6526
TCGA: ENSG00000198743
COSMIC: SLC5A3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198743	ENST00000381151	P53794

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hexose transport	REACTOME	R-HSA-189200
Inositol transporters	REACTOME	R-HSA-429593
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Na+-dependent glucose transporters	REACTOME	R-HSA-428808
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366

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References

Pubmed ID	Year	Title	Citations
24944204	2014	The transport mechanism of the human sodium/myo-inositol transporter 2 (SMIT2/SGLT6), a member of the LeuT structural family.	3
25756525	2015	Hypotonic activation of the myo-inositol transporter SLC5A3 in HEK293 cells probed by cell volumetry, confocal and super-resolution microscopy.	19
25756525	2015	Hypotonic activation of the myo-inositol transporter SLC5A3 in HEK293 cells probed by cell volumetry, confocal and super-resolution microscopy.	19
27217553	2016	Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels.	41
27217553	2016	Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels.	41
28128227	2017	Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.	31
28128227	2017	Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.	31
28793216	2017	SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.	15
28793216	2017	SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.	15
32235474	2020	Myo-Inositol Transporter SLC5A3 Associates with Degenerative Changes and Inflammation in Sporadic Inclusion Body Myositis.	10

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Citation

Dessen P

SLC5A3 (solute carrier family 5 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45558