CAPN2 (calpain 2)

2007-02-01 Affiliation

Identity

HGNC

CAPN2

LOCATION

1q41

LOCUSID

824

ALIAS

CANP2,CANPL2,CANPml,mCANP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 824
MIM: 114230
HGNC: 1479
Ensembl: ENSG00000162909

Variants:

dbSNP: 824
ClinVar: 824
TCGA: ENSG00000162909
COSMIC: CAPN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162909	ENST00000295006	P17655
ENSG00000162909	ENST00000433674	P17655
ENSG00000162909	ENST00000434648	C9JWY7

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Apoptosis	KEGG	ko04210
Focal adhesion	KEGG	ko04510
Alzheimer's disease	KEGG	ko05010
Apoptosis	KEGG	hsa04210
Focal adhesion	KEGG	hsa04510
Alzheimer's disease	KEGG	hsa05010
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Disease	REACTOME	R-HSA-1643685
Extracellular matrix organization	REACTOME	R-HSA-1474244
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Neurodegenerative Diseases	REACTOME	R-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	REACTOME	R-HSA-8862803

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
16436382	2006	TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain.	83
20150423	2010	Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).	81
18332219	2008	Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.	76
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
16652152	2006	Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.	60
12000759	2002	Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.	46
19861418	2010	Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.	46
20729206	2010	m-Calpain activation is regulated by its membrane localization and by its binding to phosphatidylinositol 4,5-bisphosphate.	39
16361262	2006	Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains.	35

Citation

Dessen P

CAPN2 (calpain 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45566/capn2-(calpain-2)