PDE3B (phosphodiesterase 3B)

2007-02-01  

Identity

HGNC
LOCATION
11p15.2
LOCUSID
ALIAS
HcGIP1,cGIPDE1
FUSION GENES

Other Information

Locus ID:

NCBI: 5140
MIM: 602047
HGNC: 8779
Ensembl: ENSG00000152270

Variants:

dbSNP: 5140
ClinVar: 5140
TCGA: ENSG00000152270
COSMIC: PDE3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152270ENST00000282096Q13370
ENSG00000152270ENST00000455098Q13370

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Insulin signaling pathwayKEGGko04910
Progesterone-mediated oocyte maturationKEGGko04914
Purine metabolismKEGGhsa00230
Insulin signaling pathwayKEGGhsa04910
Progesterone-mediated oocyte maturationKEGGhsa04914
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Regulation of lipolysis in adipocytesKEGGhsa04923
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
cGMP effectsREACTOMER-HSA-418457
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
PDE3B signallingREACTOMER-HSA-165160
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Apelin signaling pathwayKEGGhsa04371

References

Pubmed IDYearTitleCitations
380923232024A novel link between circPDE3B and ferroptosis in esophageal squamous cell carcinoma progression.0
380923232024A novel link between circPDE3B and ferroptosis in esophageal squamous cell carcinoma progression.0
329492512021Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation.5
331128062021Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism.11
329492512021Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation.5
331128062021Phosphodiesterase 2A and 3B variants are associated with primary aldosteronism.11
329673102020In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins.5
329673102020In Vitro Inhibition of Phosphodiesterase 3B (PDE 3B) by Anthocyanin-Rich Fruit Juice Extracts and Selected Anthocyanins.5
311760202019Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.3
311760202019Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic actions of PKA in human and murine endothelial cells.3
297681962018Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.20
297681962018Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.20
262830422015Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.10
262830422015Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.10
252088292014Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.28

Citation

Dessen P

PDE3B (phosphodiesterase 3B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45572/pde3b-(phosphodiesterase-3b)