INSL3 (insulin like 3)

2007-02-01  

Identity

HGNC
INSL3
LOCATION
19p13.11
LOCUSID
3640
ALIAS
RLF,RLNL,ley-I-L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3640
MIM: 146738
HGNC: 6086
Ensembl: ENSG00000248099

Variants:

dbSNP: 3640
ClinVar: 3640
TCGA: ENSG00000248099
COSMIC: INSL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000248099ENST00000317306P51460
ENSG00000248099ENST00000379695P51460
ENSG00000248099ENST00000598577M0QXQ3

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374216572024The impact of acute SARS-CoV-2 on testicular function including insulin-like factor 3 (INSL3) in men with mild COVID-19: A longitudinal study.1
374216572024The impact of acute SARS-CoV-2 on testicular function including insulin-like factor 3 (INSL3) in men with mild COVID-19: A longitudinal study.1
372088612023Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.1
378305942023New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous T-Cell Lymphoma.2
372088612023Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.1
378305942023New JAK3-INSL3 Fusion Transcript-An Oncogenic Event in Cutaneous T-Cell Lymphoma.2
354640602022Expression and Role of INSL3 in the Fetal Testis.10
356668052022The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells.6
354640602022Expression and Role of INSL3 in the Fetal Testis.10
356668052022The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells.6
330410542021New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency.4
342330482021Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy.5
344473532021Serum Concentrations and Gonadal Expression of INSL3 in Eighteen Males With 45,X/46,XY Mosaicism.1
330410542021New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency.4
342330482021Clinical value of INSL3 in the diagnosis and development of diabetic nephropathy.5

Citation

Dessen P

INSL3 (insulin like 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45583/insl3-(insulin-like-3)