STRADA (STE20 related adaptor alpha)

2007-02-01  

Identity

HGNC
STRADA
LOCATION
17q23.3
LOCUSID
92335
ALIAS
LYK5,NY-BR-96,PMSE,STRAD,STRAD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 92335
MIM: 608626
HGNC: 30172
Ensembl: ENSG00000266173

Variants:

dbSNP: 92335
ClinVar: 92335
TCGA: ENSG00000266173
COSMIC: STRADA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000266173ENST00000245865Q86YC8
ENSG00000266173ENST00000336174Q7RTN6
ENSG00000266173ENST00000375840Q7RTN6
ENSG00000266173ENST00000392950Q7RTN6
ENSG00000266173ENST00000447001Q7RTN6
ENSG00000266173ENST00000578008J3QS66
ENSG00000266173ENST00000578801J3QQS3
ENSG00000266173ENST00000579340J3KSK5
ENSG00000266173ENST00000579549J3KSA2
ENSG00000266173ENST00000580039A0A1W2PP17
ENSG00000266173ENST00000580288J3QKU4
ENSG00000266173ENST00000580338J3QKR7
ENSG00000266173ENST00000581243J3QR78
ENSG00000266173ENST00000581505A0A1W2PP17
ENSG00000266173ENST00000582026J3QRH3
ENSG00000266173ENST00000582030J3QRC1
ENSG00000266173ENST00000582137Q7RTN6
ENSG00000266173ENST00000584110A0A0G2JLH2
ENSG00000266173ENST00000617949Q86YC8
ENSG00000266173ENST00000638193A0A1W2PQF1
ENSG00000266173ENST00000638276A0A1W2PQE8
ENSG00000266173ENST00000638309A0A1W2PS04
ENSG00000266173ENST00000638698A0A1W2PNV7
ENSG00000266173ENST00000638702Q7RTN6
ENSG00000266173ENST00000638708A0A1W2PPJ9
ENSG00000266173ENST00000638718A0A1W2PQ20
ENSG00000266173ENST00000638888A0A1W2PPG2
ENSG00000266173ENST00000639135A0A1W2PQ00
ENSG00000266173ENST00000639164A0A1W2PRI8
ENSG00000266173ENST00000639521A0A1W2PR44
ENSG00000266173ENST00000639603A0A1W2PPI1
ENSG00000266173ENST00000639835Q7RTN6
ENSG00000266173ENST00000640086A0A1W2PR00
ENSG00000266173ENST00000640174A0A1W2PP78
ENSG00000266173ENST00000640397A0A1W2PRQ6
ENSG00000266173ENST00000640679A0A1W2PNV7
ENSG00000266173ENST00000640741A0A1W2PNV1
ENSG00000266173ENST00000640827A0A1W2PR65
ENSG00000266173ENST00000640870A0A1W2PRW9
ENSG00000266173ENST00000640979A0A1W2PPM8
ENSG00000266173ENST00000640999Q7RTN6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
mTOR signallingREACTOMER-HSA-165159
Energy dependent regulation of mTOR by LKB1-AMPKREACTOMER-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
332475132021Two further cases of polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome, caused by a truncating variant in STRADA.2
334401202021Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα.4
332475132021Two further cases of polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome, caused by a truncating variant in STRADA.2
334401202021Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα.4
271701582016Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE).9
271701582016Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE).9
204243262010STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice.65
204243262010STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice.65
188543182009C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.33
193862642009Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.89
195131072009ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.75
198929432009Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.160
188543182009C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.33
193862642009Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.89
195131072009ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.75

Citation

Dessen P

STRADA (STE20 related adaptor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45584/strada-(ste20-related-adaptor-alpha)