GIT2 (GIT ArfGAP 2)

2007-02-01  

Identity

HGNC
LOCATION
12q24.11
LOCUSID
ALIAS
CAT-2,CAT2,PKL
FUSION GENES

Other Information

Locus ID:

NCBI: 9815
MIM: 608564
HGNC: 4273
Ensembl: ENSG00000139436

Variants:

dbSNP: 9815
ClinVar: 9815
TCGA: ENSG00000139436
COSMIC: GIT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139436ENST00000320063F8W822
ENSG00000139436ENST00000354574F8WAK2
ENSG00000139436ENST00000355312Q14161
ENSG00000139436ENST00000361006Q14161
ENSG00000139436ENST00000457474Q14161
ENSG00000139436ENST00000547815Q14161
ENSG00000139436ENST00000547815Q6FI58
ENSG00000139436ENST00000550186R4GNG3
ENSG00000139436ENST00000551209F8VXI9
ENSG00000139436ENST00000553118Q14161

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165980762006The multifunctional GIT family of proteins.111
152127612004The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors.57
166282232006GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover.34
112510772001An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization.32
271820612016Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.27
238644332013Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1).13
256053342015Nuclear GIT2 is an ATM substrate and promotes DNA repair.11
272385702016EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.10
276694372017The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion.6
165013062006Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.4

Citation

Dessen P

GIT2 (GIT ArfGAP 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45589/git2-(git-arfgap-2)