PDYN (prodynorphin)

2007-02-01 Affiliation

Identity

HGNC

PDYN

LOCATION

20p13

LOCUSID

5173

ALIAS

ADCA,PENKB,SCA23

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5173
MIM: 131340
HGNC: 8820
Ensembl: ENSG00000101327

Variants:

dbSNP: 5173
ClinVar: 5173
TCGA: ENSG00000101327
COSMIC: PDYN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000101327	ENST00000217305	P01213
ENSG00000101327	ENST00000539905	P01213
ENSG00000101327	ENST00000540134	P01213
ENSG00000101327	ENST00000650824	A0A494C1J4
ENSG00000101327	ENST00000650874	A0A494C0B1
ENSG00000101327	ENST00000650937	A0A494C197
ENSG00000101327	ENST00000651328	A0A494C1U2
ENSG00000101327	ENST00000651684	A0A494C0B3
ENSG00000101327	ENST00000651882	A0A494C0X3
ENSG00000101327	ENST00000651996	A0A494C0Y8
ENSG00000101327	ENST00000652436	A0A494C1E3

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Opioid Signalling	REACTOME	R-HSA-111885
G-protein activation	REACTOME	R-HSA-202040

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation	associated		PD	19298317
PA452618	opioids	Chemical	ClinicalAnnotation	associated		PD	19298317

References

Pubmed ID	Year	Title	Citations
37177778	2023	Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms.	0
37177778	2023	Effect of PDYN and OPRK1 polymorphisms on the risk of alcohol use disorder and the intensity of depressive symptoms.	0
32597371	2022	Prodynorphin (PDYN) gene polymorphisms in Turkish patients with methamphetamine use disorder, changes in PDYN serum levels in withdrawal and the relationship between PDYN, temperament and depression.	1
32597371	2022	Prodynorphin (PDYN) gene polymorphisms in Turkish patients with methamphetamine use disorder, changes in PDYN serum levels in withdrawal and the relationship between PDYN, temperament and depression.	1
32526201	2020	Alpha-neoendorphin can reduce UVB-induced skin photoaging by activating cellular autophagy.	7
32526201	2020	Alpha-neoendorphin can reduce UVB-induced skin photoaging by activating cellular autophagy.	7
30936032	2019	Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use.	3
31510971	2019	Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis.	2
30936032	2019	Association of variants of prodynorphin promoter 68-bp repeats in caucasians with opioid dependence diagnosis: Effect on age trajectory of heroin use.	3
31510971	2019	Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis.	2
28830794	2018	Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor.	13
28968778	2018	Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain.	4
29383684	2018	Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics.	10
29925858	2018	Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.	10
28830794	2018	Regulation of gene transcription in bipolar disorders: Role of DNA methylation in the relationship between prodynorphin and brain derived neurotrophic factor.	13

Citation

Dessen P

PDYN (prodynorphin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45605/pdyn-(prodynorphin)