B3GAT1 (beta-1,3-glucuronyltransferase 1)

2007-02-01  

Identity

HGNC
LOCATION
11q25
LOCUSID
ALIAS
CD57,GLCATP,GLCUATP,HNK1,LEU7,NK-1,NK1
FUSION GENES

Other Information

Locus ID:

NCBI: 27087
MIM: 151290
HGNC: 921
Ensembl: ENSG00000109956

Variants:

dbSNP: 27087
ClinVar: 27087
TCGA: ENSG00000109956
COSMIC: B3GAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109956ENST00000312527Q9P2W7
ENSG00000109956ENST00000392580Q9P2W7
ENSG00000109956ENST00000524765Q9P2W7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesisREACTOMER-HSA-1971475
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Mannose type O-glycan biosynthesisKEGGko00515
Mannose type O-glycan biosynthesisKEGGhsa00515

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124336882003Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells.338
207331592010CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset.232
206969442010Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.224
247405022014Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus.70
158791032005Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57.62
195643392009Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.57
236374202013Human cytomegalovirus-induced NKG2C(hi) CD57(hi) natural killer cells are effectors dependent on humoral antiviral immunity.46
232878652013Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production.44
254265582015Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57.29
245858932014Low proportions of CD28- CD8+ T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV infection.28

Citation

Dessen P

B3GAT1 (beta-1,3-glucuronyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45625/b3gat1-(beta-1-3-glucuronyltransferase-1)