RNF2 (ring finger protein 2)

2007-02-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
BAP-1,BAP1,DING,HIPI3,RING1B,RING2
FUSION GENES

Other Information

Locus ID:

NCBI: 6045
MIM: 608985
HGNC: 10061
Ensembl: ENSG00000121481

Variants:

dbSNP: 6045
ClinVar: 6045
TCGA: ENSG00000121481
COSMIC: RNF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121481ENST00000367509Q99496
ENSG00000121481ENST00000367510Q99496
ENSG00000121481ENST00000453650X6RFN3

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362713152023The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression.0
369320262023N-Terminally arginylated ubiquitin is attached to histone H2A by RING1B E3 ligase in human cells.0
370378162023RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination.3
378062492023M phase-specific interaction between SBDS and RNF2 at the mitotic spindles regulates mitotic progression.0
362713152023The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression.0
369320262023N-Terminally arginylated ubiquitin is attached to histone H2A by RING1B E3 ligase in human cells.0
370378162023RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination.3
378062492023M phase-specific interaction between SBDS and RNF2 at the mitotic spindles regulates mitotic progression.0
330875302022Hospital-acquired serum phosphate derangements and their associated in-hospital mortality.4
346701172022RNF2 promotes the progression of colon cancer by regulating ubiquitination and degradation of IRF4.5
351290562022DNA methyltransferase 3 beta regulates promoter methylation of microRNA-149 to augment esophageal squamous cell carcinoma development through the ring finger protein 2/Wnt/β-catenin axis.7
351582102022SBDS interacts with RNF2 and is degraded through RNF2-dependent ubiquitination.0
361983462022SPI1 mediates transcriptional activation of TPX2 and RNF2 to regulate the radiosensitivity of lung squamous cell carcinoma.1
330875302022Hospital-acquired serum phosphate derangements and their associated in-hospital mortality.4
346701172022RNF2 promotes the progression of colon cancer by regulating ubiquitination and degradation of IRF4.5

Citation

Dessen P

RNF2 (ring finger protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45636/rnf2-(ring-finger-protein-2)