Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3593
MIM: 161561
HGNC: 5970
Ensembl: ENSG00000113302
Variants:
dbSNP: 3593
ClinVar: 3593
TCGA: ENSG00000113302
COSMIC: IL12B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000113302 | ENST00000231228 | P29460 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10004 | adalimumab | Chemical | VariantAnnotation | ambiguous | PD | 27564082, 29192552 | |
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 27670765 | |
| PA166048654 | ustekinumab | Chemical | ClinicalAnnotation, LabelAnnotation | associated | PD | 27564082 | |
| PA445451 | Psoriasis | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 27564082, 27670765, 28470127, 29192552 | |
| PA449515 | etanercept | Chemical | VariantAnnotation | associated | PD | 28470127 | |
| PA452639 | infliximab | Chemical | VariantAnnotation | associated | PD | 29192552 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38167707 | 2024 | IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity. | 1 |
| 38394507 | 2024 | Interleukin gene polymorphisms and alopecia areata: A systematic review and meta-analysis. | 0 |
| 38167707 | 2024 | IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity. | 1 |
| 38394507 | 2024 | Interleukin gene polymorphisms and alopecia areata: A systematic review and meta-analysis. | 0 |
| 36328955 | 2023 | Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients. | 0 |
| 36370169 | 2023 | Elevated expression of interleukin-27, IL-35, and decreased IL-12 in patients with thyroid-associated ophthalmopathy. | 1 |
| 36842370 | 2023 | Interleukin 12B rs3212227 and rs6887695 single nucleotide polymorphisms are associated with the susceptibility to preeclampsia: Genetic, haplotype and bioinformatics analysis. | 0 |
| 37069321 | 2023 | IL-12 and IL-23 pathway inhibition in inflammatory bowel disease. | 17 |
| 37543802 | 2023 | IL12B and IL17 genes polymorphisms associated with differential susceptibility to juvenile idiopathic arthritis and juvenile-onset systemic lupus erythematosus in Chinese children. | 0 |
| 38033168 | 2023 | Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda. | 0 |
| 38223634 | 2023 | Association between interleukin-12 +1188A/C polymorphism and the risk of tuberculosis: A meta-analysis. | 0 |
| 36328955 | 2023 | Association between gene polymorphisms of IL-12, IL-12 receptor and IL-27 and organ involvement in Iranian endometriosis patients. | 0 |
| 36370169 | 2023 | Elevated expression of interleukin-27, IL-35, and decreased IL-12 in patients with thyroid-associated ophthalmopathy. | 1 |
| 36842370 | 2023 | Interleukin 12B rs3212227 and rs6887695 single nucleotide polymorphisms are associated with the susceptibility to preeclampsia: Genetic, haplotype and bioinformatics analysis. | 0 |
| 37069321 | 2023 | IL-12 and IL-23 pathway inhibition in inflammatory bowel disease. | 17 |
Citation
Dessen P
IL12B (interleukin 12B)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45649/il12b-(interleukin-12b)
