PTGES3 (prostaglandin E synthase 3)

2007-02-01  

Identity

HGNC
PTGES3
LOCATION
12q13.3
LOCUSID
10728
ALIAS
P23,TEBP,cPGES
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10728
MIM: 607061
HGNC: 16049
Ensembl: ENSG00000110958

Variants:

dbSNP: 10728
ClinVar: 10728
TCGA: ENSG00000110958
COSMIC: PTGES3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110958ENST00000262033Q15185
ENSG00000110958ENST00000262033A0A024RB32
ENSG00000110958ENST00000414274Q15185
ENSG00000110958ENST00000436399Q15185
ENSG00000110958ENST00000448157Q15185
ENSG00000110958ENST00000456859B4DDC6
ENSG00000110958ENST00000614328A0A087WYT3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arachidonic acid metabolismKEGGko00590
Arachidonic acid metabolismKEGGhsa00590
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)REACTOMER-HSA-2162123
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1 activationREACTOMER-HSA-3371511
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
Aryl hydrocarbon receptor signallingREACTOMER-HSA-8937144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382457172024The integration of multidisciplinary approaches revealed PTGES3 as a novel drug target for breast cancer treatment.0
382457172024The integration of multidisciplinary approaches revealed PTGES3 as a novel drug target for breast cancer treatment.0
365203072023p23 and Aha1: Distinct Functions Promote Client Maturation.1
374169272023Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma.0
365203072023p23 and Aha1: Distinct Functions Promote Client Maturation.1
374169272023Effect of PTGES3 on the Prognosis and Immune Regulation in Lung Adenocarcinoma.0
349203302022PTGES3 is a Putative Prognostic Marker in Breast Cancer.5
349379362022Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism.45
349203302022PTGES3 is a Putative Prognostic Marker in Breast Cancer.5
349379362022Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism.45
335472942021Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.22
335472942021Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.22
320722322020A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome.14
324141292020Selective Autophagy Maintains the Aryl Hydrocarbon Receptor Levels in HeLa Cells: A Mechanism That Is Dependent on the p23 Co-Chaperone.7
320722322020A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome.14

Citation

Dessen P

PTGES3 (prostaglandin E synthase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45663/ptges3-(prostaglandin-e-synthase-3)