TUBB3 (tubulin beta 3 class III)

2007-02-01  

Identity

HGNC
LOCATION
16q24.3
LOCUSID
ALIAS
CDCBM,CDCBM1,CFEOM3,CFEOM3A,FEOM3,TUBB4,beta-4
FUSION GENES

Other Information

Locus ID:

NCBI: 10381
MIM: 602661
HGNC: 20772
Ensembl: ENSG00000258947

Variants:

dbSNP: 10381
ClinVar: 10381
TCGA: ENSG00000258947
COSMIC: TUBB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000258947ENST00000315491Q13509
ENSG00000258947ENST00000553656G3V4U2
ENSG00000258947ENST00000553967G3V2N6
ENSG00000258947ENST00000554336G3V2R8
ENSG00000258947ENST00000554444Q13509
ENSG00000258947ENST00000555576G3V5W4
ENSG00000258947ENST00000555609G3V3J6
ENSG00000258947ENST00000555810G3V2A3
ENSG00000258947ENST00000556536G3V3R4
ENSG00000258947ENST00000556565G3V542
ENSG00000258947ENST00000557262G3V4U2
ENSG00000258947ENST00000557490G3V3W7
ENSG00000258947ENST00000625617G3V3R4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gap junctionKEGGko04540
Pathogenic Escherichia coli infectionKEGGko05130
Gap junctionKEGGhsa04540
Pathogenic Escherichia coli infectionKEGGhsa05130
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381157972024NOTCH3 promotes docetaxel resistance of prostate cancer cells through regulating TUBB3 and MAPK signaling pathway.1
381157972024NOTCH3 promotes docetaxel resistance of prostate cancer cells through regulating TUBB3 and MAPK signaling pathway.1
376468902023OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer.0
376468902023OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer.0
357658332022Infantile esotropia in a family with TUBB3 mutation associated congenital fibrosis of extraocular muscles.3
363096172022Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport.8
357658332022Infantile esotropia in a family with TUBB3 mutation associated congenital fibrosis of extraocular muscles.3
363096172022Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated transport.8
325221062021Association of high TUBB3 with resistance to adjuvant docetaxel-based chemotherapy in gastric cancer: translational study of ITACA-S.4
338225142021TUBB3 Promotes Growth and Invasion of Gallbladder Cancer Cells by Akt/mTOR Signal Pathway.4
338823062021Airway basal stem cells generate distinct subpopulations of PNECs.15
339211322021TUBB3 M323V Syndrome Presents with Infantile Nystagmus.6
343186302021Exosomal TUBB3 mRNA expression of metastatic castration-resistant prostate cancer patients: Association with patient outcome under abiraterone.9
346525762021TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy.7
325221062021Association of high TUBB3 with resistance to adjuvant docetaxel-based chemotherapy in gastric cancer: translational study of ITACA-S.4

Citation

Dessen P

TUBB3 (tubulin beta 3 class III)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45664/tubb3-(tubulin-beta-3-class-iii)