TUBB3 (tubulin beta 3 class III)

2007-02-01  

Identity

HGNC
LOCATION
16q24.3
LOCUSID
ALIAS
CDCBM,CDCBM1,CFEOM3,CFEOM3A,FEOM3,TUBB4,beta-4
FUSION GENES

Other Information

Locus ID:

NCBI: 10381
MIM: 602661
HGNC: 20772
Ensembl: ENSG00000258947

Variants:

dbSNP: 10381
ClinVar: 10381
TCGA: ENSG00000258947
COSMIC: TUBB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000258947ENST00000315491Q13509
ENSG00000258947ENST00000553656G3V4U2
ENSG00000258947ENST00000553967G3V2N6
ENSG00000258947ENST00000554336G3V2R8
ENSG00000258947ENST00000554444Q13509
ENSG00000258947ENST00000555576G3V5W4
ENSG00000258947ENST00000555609G3V3J6
ENSG00000258947ENST00000555810G3V2A3
ENSG00000258947ENST00000556536G3V3R4
ENSG00000258947ENST00000556565G3V542
ENSG00000258947ENST00000557262G3V4U2
ENSG00000258947ENST00000557490G3V3W7
ENSG00000258947ENST00000625617G3V3R4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gap junctionKEGGko04540
Pathogenic Escherichia coli infectionKEGGko05130
Gap junctionKEGGhsa04540
Pathogenic Escherichia coli infectionKEGGhsa05130
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200745212010Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.182
156715592005Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients.106
208292272010Mutations in the neuronal ß-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defects.82
166755702006Class III beta-tubulin overexpression is a marker of poor clinical outcome in advanced ovarian cancer patients.63
160618642005Expression of class III {beta}-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy.54
127892632003Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer.53
210451572010Class III beta-tubulin expression predicts prostate tumor aggressiveness and patient response to docetaxel-based chemotherapy.48
129055302003Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxel.45
271292032016Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin.41
194059532009Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.38

Citation

Dessen P

TUBB3 (tubulin beta 3 class III)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45664/tubb3-(tubulin-beta-3-class-iii)