ST3GAL4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4)

2007-02-01  

Identity

HGNC
LOCATION
11q24.2
LOCUSID
ALIAS
CGS23,NANTA3,SAT3,SIAT4,SIAT4C,ST-4,ST3GalA.2,ST3GalIV,STZ,gal-NAc6S
FUSION GENES

Other Information

Locus ID:

NCBI: 6484
MIM: 104240
HGNC: 10864
Ensembl: ENSG00000110080

Variants:

dbSNP: 6484
ClinVar: 6484
TCGA: ENSG00000110080
COSMIC: ST3GAL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110080ENST00000227495Q11206
ENSG00000110080ENST00000227495Q6IBE6
ENSG00000110080ENST00000356132Q11206
ENSG00000110080ENST00000392669Q11206
ENSG00000110080ENST00000444328Q11206
ENSG00000110080ENST00000449406Q11206
ENSG00000110080ENST00000524860E9PMC7
ENSG00000110080ENST00000526311E9PPJ6
ENSG00000110080ENST00000526727Q11206
ENSG00000110080ENST00000528858E9PQZ2
ENSG00000110080ENST00000530591Q11206
ENSG00000110080ENST00000530591Q6IBE6
ENSG00000110080ENST00000531217E9PN64
ENSG00000110080ENST00000532243Q11206
ENSG00000110080ENST00000534083Q11206
ENSG00000110080ENST00000534452E9PNJ9
ENSG00000110080ENST00000534457Q11206
ENSG00000110080ENST00000534733E9PKJ2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGko00601
Glycosphingolipid biosynthesis - lacto and neolacto seriesKEGGhsa00601
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
N-Glycan antennae elongationREACTOMER-HSA-975577
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195208072009Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.57
197816612010Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.33
254989122015ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
237991302013Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.21
237268342013α2,3-Sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues.18
123750292002Clinical significance of ST3Gal IV expression in human renal cell carcinoma.11
170549482006Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene.11
211402422012Altered mRNA expressions of sialyltransferases in human gastric cancer tissues.11

Citation

Dessen P

ST3GAL4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45689/st3gal4-(st3-beta-galactoside-alpha-2-3-sialyltransferase-4)