NR6A1 (nuclear receptor subfamily 6 group A member 1)

2007-02-01  

Identity

HGNC
NR6A1
LOCATION
9q33.3
LOCUSID
2649
ALIAS
CT150,GCNF,GCNF1,NR61,RTR,hGCNF,hRTR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2649
MIM: 602778
HGNC: 7985
Ensembl: ENSG00000148200

Variants:

dbSNP: 2649
ClinVar: 2649
TCGA: ENSG00000148200
COSMIC: NR6A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148200ENST00000344523Q15406
ENSG00000148200ENST00000373584Q15406
ENSG00000148200ENST00000373584F1DAM1
ENSG00000148200ENST00000416460Q15406
ENSG00000148200ENST00000475178C9JDI9
ENSG00000148200ENST00000487099Q15406
ENSG00000148200ENST00000487099F1D8S0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferationREACTOMER-HSA-2892247

References

Pubmed IDYearTitleCitations
379039712023Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.2
379039712023Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.2
346893842021Novel LAMC2 fusion protein has tumor-promoting properties in ovarian carcinoma.10
346893842021Novel LAMC2 fusion protein has tumor-promoting properties in ovarian carcinoma.10
330062002020hsa_circ_001653 up-regulates NR6A1 expression and elicits gastric cancer progression by binding to microRNA-377.5
330062002020hsa_circ_001653 up-regulates NR6A1 expression and elicits gastric cancer progression by binding to microRNA-377.5
313156162019NR6A1 regulates lipid metabolism through mammalian target of rapamycin complex 1 in HepG2 cells.12
313156162019NR6A1 regulates lipid metabolism through mammalian target of rapamycin complex 1 in HepG2 cells.12
290574992018GCNF regulates OCT4 expression through its interactions with nuclear receptor binding elements in NCCIT cells.1
290574992018GCNF regulates OCT4 expression through its interactions with nuclear receptor binding elements in NCCIT cells.1
267699702016Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.13
267699702016Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells.13
234951372013Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells.7
235327702013Expression screening of cancer/testis genes in prostate cancer identifies NR6A1 as a novel marker of disease progression and aggressiveness.13
234951372013Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells.7

Citation

Dessen P

NR6A1 (nuclear receptor subfamily 6 group A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45696/nr6a1-(nuclear-receptor-subfamily-6-group-a-member-1)