GH2 (growth hormone 2)

2007-02-01  

Identity

HGNC
GH2
LOCATION
17q23.3
LOCUSID
2689
ALIAS
GH-V,GHB2,GHL,GHV,hGH-V
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2689
MIM: 139240
HGNC: 4262
Ensembl: ENSG00000136487

Variants:

dbSNP: 2689
ClinVar: 2689
TCGA: ENSG00000136487
COSMIC: GH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136487ENST00000332800P01242
ENSG00000136487ENST00000423893P01242
ENSG00000136487ENST00000423893A0A0M6L0J9
ENSG00000136487ENST00000449787P01242
ENSG00000136487ENST00000456543P01242
ENSG00000136487ENST00000622506A0A087WXJ5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Neuroactive ligand-receptor interactionKEGGko04080
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Neuroactive ligand-receptor interactionKEGGhsa04080
Jak-STAT signaling pathwayKEGGhsa04630
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Growth hormone receptor signalingREACTOMER-HSA-982772
Prolactin receptor signalingREACTOMER-HSA-1170546

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
265895702015Lower levels of placental growth hormone in early pregnancy in women with type 1 diabetes and large for gestational age infants.4
265895702015Lower levels of placental growth hormone in early pregnancy in women with type 1 diabetes and large for gestational age infants.4
240353092013Developmental programming of growth: genetic variant in GH2 gene encoding placental growth hormone contributes to adult height determination.8
240353092013Developmental programming of growth: genetic variant in GH2 gene encoding placental growth hormone contributes to adult height determination.8
223634002012Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.10
223870442012Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.14
224896242012Maternal serum placental growth hormone at 11-13 weeks' gestation in pregnancies delivering small for gestational age neonates.5
223634002012Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.10
223870442012Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.14
224896242012Maternal serum placental growth hormone at 11-13 weeks' gestation in pregnancies delivering small for gestational age neonates.5
200059262010hGH-V gene expression and promoter activity under glucose and 5-azacytidine (5azaC) effects.2
204033542010A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence.35
200059262010hGH-V gene expression and promoter activity under glucose and 5-azacytidine (5azaC) effects.2
204033542010A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence.35
198449412009Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndrome.4

Citation

Dessen P

GH2 (growth hormone 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45698/css/humanGenome