ASF1A (anti-silencing function 1A histone chaperone)

2007-02-01  

Identity

HGNC
ASF1A
LOCATION
6q22.31
LOCUSID
25842
ALIAS
CGI-98,CIA,HSPC146

Other Information

Locus ID:

NCBI: 25842
MIM: 609189
HGNC: 20995
Ensembl: ENSG00000111875

Variants:

dbSNP: 25842
ClinVar: 25842
TCGA: ENSG00000111875
COSMIC: ASF1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111875ENST00000229595Q9Y294

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
385613842024Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma.0
385613842024Identification of ASF1A and HJURP by global H3-H4 histone chaperone analysis as a prognostic two-gene model in hepatocellular carcinoma.0
351360692022Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.9
351776092022RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.6
354723312022Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells.7
361846592022Histone chaperone ASF1A accelerates chronic myeloid leukemia blast crisis by activating Notch signaling.3
351360692022Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.9
351776092022RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.6
354723312022Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells.7
361846592022Histone chaperone ASF1A accelerates chronic myeloid leukemia blast crisis by activating Notch signaling.3
335034152021Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A.7
335762642021Elevated expression of ASF1B correlates with poor prognosis in human lung adenocarcinoma.12
335034152021Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A.7
335762642021Elevated expression of ASF1B correlates with poor prognosis in human lung adenocarcinoma.12
317448292020In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma.95

Citation

Dessen P

ASF1A (anti-silencing function 1A histone chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45707/asf1a-(anti-silencing-function-1a-histone-chaperone)