Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4277
MIM: 602436
HGNC: 7091
Ensembl: ENSG00000204516
IMGT/GENE-DB:
Variants:
dbSNP: 4277
ClinVar: 4277
TCGA: ENSG00000204516
COSMIC: MICB
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000204516 | ENST00000252229 | X6R344 |
| ENSG00000204516 | ENST00000399150 | Q29980 |
| ENSG00000204516 | ENST00000538442 | F5H7Q8 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164749390 | peginterferon alfa-2a | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164784024 | peginterferon alfa-2b | Chemical | ClinicalAnnotation | associated | PD | ||
| PA446863 | Hepatitis C, Chronic | Disease | ClinicalAnnotation | associated | PD | ||
| PA451241 | ribavirin | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37878820 | 2024 | MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death. | 1 |
| 38205878 | 2024 | Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients. | 0 |
| 37878820 | 2024 | MICB Genomic Variant Is Associated with NKG2D-mediated Acute Lung Injury and Death. | 1 |
| 38205878 | 2024 | Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients. | 0 |
| 36898046 | 2023 | Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis. | 0 |
| 36958849 | 2023 | Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC). | 2 |
| 36898046 | 2023 | Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis. | 0 |
| 36958849 | 2023 | Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC). | 2 |
| 35525711 | 2022 | HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals from the Bulgarian population. | 0 |
| 35525711 | 2022 | HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals from the Bulgarian population. | 0 |
| 33835601 | 2021 | Associations of high-resolution-typing-defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients. | 1 |
| 34012432 | 2021 | Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus. | 7 |
| 34372495 | 2021 | Intracellular Sequestration of the NKG2D Ligand MIC B by Species F Adenovirus. | 2 |
| 34482362 | 2021 | Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition. | 8 |
| 33835601 | 2021 | Associations of high-resolution-typing-defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients. | 1 |
Citation
Dessen P
MICB (MHC class I polypeptide-related sequence B)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45710/micb-(mhc-class-i-polypeptide-related-sequence-b)
