Identity
HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
DBP,DBP-maf,DBP/GC,GRD3,Gc-MAF,GcMAF,HEL-S-51,VDB,VDBG,VDBP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2638
MIM: 139200
HGNC: 4187
Ensembl: ENSG00000145321
Variants:
dbSNP: 2638
ClinVar: 2638
TCGA: ENSG00000145321
COSMIC: GC
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10040 | cetuximab | Chemical | VariantAnnotation | associated | PD | 29208668 | |
| PA130232992 | bevacizumab | Chemical | VariantAnnotation | associated | PD | 29208668 | |
| PA164760843 | deferasirox | Chemical | ClinicalAnnotation | associated | PD | 30651574 | |
| PA166123207 | overall survival | Disease | VariantAnnotation | associated | PD | 29208668 | |
| PA445058 | Neoplasm Metastasis | Disease | VariantAnnotation | associated | PD | 29208668 | |
| PA446108 | Colorectal Neoplasms | Disease | VariantAnnotation | associated | PD | 29208668 | |
| PA446432 | beta-Thalassemia | Disease | ClinicalAnnotation | associated | PD | 30651574 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38732523 | 2024 | Relationship between Vitamin D3 Deficiency, Metabolic Syndrome and VDR, GC, and CYP2R1 Gene Polymorphisms. | 1 |
| 39068475 | 2024 | Association of rs4588 polymorphism in vitamin D binding protein gene with polycystic ovarian syndrome in Iranian women: a case-control study. | 0 |
| 38732523 | 2024 | Relationship between Vitamin D3 Deficiency, Metabolic Syndrome and VDR, GC, and CYP2R1 Gene Polymorphisms. | 1 |
| 39068475 | 2024 | Association of rs4588 polymorphism in vitamin D binding protein gene with polycystic ovarian syndrome in Iranian women: a case-control study. | 0 |
| 37175534 | 2023 | Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis. | 3 |
| 37407930 | 2023 | Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma: a pilot study. | 2 |
| 37494457 | 2023 | Association of functional, inherited vitamin D-binding protein variants with melanoma-specific death. | 0 |
| 37553799 | 2023 | Vitamin D receptor and binding protein genes variants in patients with migraine. | 1 |
| 37587824 | 2023 | Sex-Specific Variations in Vitamin D and Vitamin D Binding Protein (Vdbp) and Flipped Pattern of their Association in Preeclamptic Women with Dyslipidemia. | 0 |
| 37814286 | 2023 | Association of rs2282679 polymorphism in vitamin D binding protein gene (GC) with the risk of vitamin D deficiency in an iranian population: season-specific vitamin D status. | 0 |
| 37888613 | 2023 | The role of free vitamin D and vitamin D binding protein in SARS-Cov-2 infection in children. | 0 |
| 37898838 | 2023 | Association of Single Nucleotide Polymorphism in VDR, GC Globulin and CYP2R1 with the Risk of Esophageal Cancer. | 0 |
| 37929021 | 2023 | Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait. | 1 |
| 37929856 | 2023 | Association between the genetic variant in the vitamin D pathway (rs2282679), circulating 25-hydroxyvitamin D levels, insulin resistance and metabolic syndrome criteria. | 0 |
| 38066559 | 2023 | Vitamin D receptor rs3782905 and vitamin D binding protein rs7041 polymorphisms are associated with hepatocellular carcinoma susceptibility in cirrhotic HCV patients. | 0 |
Citation
Dessen P
GC (GC vitamin D binding protein)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45713/gc-(gc-vitamin-d-binding-protein)
