Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7097
MIM: 603028
HGNC: 11848
Ensembl: ENSG00000137462
Variants:
dbSNP: 7097
ClinVar: 7097
TCGA: ENSG00000137462
COSMIC: TLR2
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 24776844, 28696418 | |
| PA443750 | Colitis, Ulcerative | Disease | ClinicalAnnotation | associated | PD | 24776844 | |
| PA443815 | Crohn Disease | Disease | ClinicalAnnotation | associated | PD | 24776844 | |
| PA445451 | Psoriasis | Disease | ClinicalAnnotation | associated | PD | 24776844, 28696418 | |
| PA446116 | Inflammatory Bowel Diseases | Disease | ClinicalAnnotation | associated | PD | 24776844, 28696418 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37585174 | 2024 | Synonymous mutations in TLR2 and TLR9 genes decrease COPD susceptibility in the Chinese Han population. | 1 |
| 37718198 | 2024 | Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia. | 0 |
| 37977066 | 2024 | The expression of Nrf2 and TLRs in ear effusion in children with different types of otitis media and their relationship with inflammatory factors. | 0 |
| 38062733 | 2024 | Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression. | 0 |
| 38251423 | 2024 | Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1. | 2 |
| 38296390 | 2024 | Correlation of polymorphism in Toll-Like Receptor (TLR1 and TLR2) genes with susceptibility of pulmonary tuberculosis in Doda region of India. | 0 |
| 38344758 | 2024 | P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association with PARP9. | 0 |
| 38368639 | 2024 | p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2. | 0 |
| 38394259 | 2024 | miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway. | 0 |
| 38419396 | 2024 | Exploring the Impact of TLR-2 Signaling on miRNA Dysregulation in Intervertebral Disc Degeneration. | 0 |
| 38420813 | 2024 | Analysis of TLR2 in Primary Endocrine Resistant of Breast Cancer. | 0 |
| 38492105 | 2024 | Expression of TLR2, IL-1β, and IL-10 Genes as a Possible Factor of Successful or Pathological Aging in Nonagenarians. | 0 |
| 38648901 | 2024 | TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne. | 0 |
| 38797288 | 2024 | Identification of toll-like receptor 2 as a key regulator of neuronal apoptosis in vascular dementia by bioinformatics analysis and experimental validation. | 0 |
| 38868969 | 2024 | Strong association of TLR2 and TLR3 polymorphisms with keratoacanthoma and common warts: a case-control study. | 0 |
Citation
Dessen P
TLR2 (toll like receptor 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45714/tlr2-(toll-like-receptor-2)
