LTB4R (leukotriene B4 receptor)

2007-02-01  

Identity

HGNC
LTB4R
LOCATION
14q12
LOCUSID
1241
ALIAS
BLT1,BLTR,CMKRL1,GPR16,LTB4R1,LTBR1,P2RY7,P2Y7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1241
MIM: 601531
HGNC: 6713
Ensembl: ENSG00000213903

Variants:

dbSNP: 1241
ClinVar: 1241
TCGA: ENSG00000213903
COSMIC: LTB4R

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213903ENST00000345363Q15722
ENSG00000213903ENST00000396782Q15722
ENSG00000213903ENST00000396789Q15722
ENSG00000213903ENST00000553481G3V244
ENSG00000213903ENST00000556141G3V4Q5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Leukotriene receptorsREACTOMER-HSA-391906
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
352416772022Structural basis of leukotriene B4 receptor 1 activation.13
352416772022Structural basis of leukotriene B4 receptor 1 activation.13
329567592021A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells.5
340169732021Structural insights on ligand recognition at the human leukotriene B4 receptor 1.7
343393122021SPM Receptor Expression and Localization in Irradiated Salivary Glands.1
329567592021A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells.5
340169732021Structural insights on ligand recognition at the human leukotriene B4 receptor 1.7
343393122021SPM Receptor Expression and Localization in Irradiated Salivary Glands.1
324395962020The role of the LTB4-BLT1 axis in health and disease.33
324395962020The role of the LTB4-BLT1 axis in health and disease.33
313390922019A possible relationship between Thromboxane B2 and Leukotriene B4 and the encapsulation of Dirofilaria repens worms in human subcutaneous dirofilariasis.2
313390922019A possible relationship between Thromboxane B2 and Leukotriene B4 and the encapsulation of Dirofilaria repens worms in human subcutaneous dirofilariasis.2
293090552018Na(+)-mimicking ligands stabilize the inactive state of leukotriene B(4) receptor BLT1.31
298599382018BLT1-mediated O-GlcNAcylation is required for NOX2-dependent migration, exocytotic degranulation and IL-8 release of human mast cell induced by Trichomonas vaginalis-secreted LTB(4).5
293090552018Na(+)-mimicking ligands stabilize the inactive state of leukotriene B(4) receptor BLT1.31

Citation

Dessen P

LTB4R (leukotriene B4 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45728/ltb4r-(leukotriene-b4-receptor)