CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)

2007-02-01  

Identity

HGNC
CHRNA7
LOCATION
15q13.2
LOCUSID
1139
ALIAS
CHRNA7-2,NACHRA7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1139
MIM: 118511
HGNC: 1960
Ensembl: ENSG00000175344

Variants:

dbSNP: 1139
ClinVar: 1139
TCGA: ENSG00000175344
COSMIC: CHRNA7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175344ENST00000306901P36544
ENSG00000175344ENST00000437966P36544
ENSG00000175344ENST00000454250P36544
ENSG00000175344ENST00000635722A0A1B0GVP9
ENSG00000175344ENST00000635759A0A1B0GTT0
ENSG00000175344ENST00000635883A0A1B0GVN6
ENSG00000175344ENST00000635884A0A1B0GTT9
ENSG00000175344ENST00000635978A0A1B0GW52
ENSG00000175344ENST00000636044A0A1B0GU56
ENSG00000175344ENST00000636271A0A1B0GV25
ENSG00000175344ENST00000636440A0A1B0GV44
ENSG00000175344ENST00000636603A0A1B0GVH2
ENSG00000175344ENST00000636850A0A1B0GU93
ENSG00000175344ENST00000637033A0A1B0GVH2
ENSG00000175344ENST00000637183A0A1B0GV43
ENSG00000175344ENST00000637348A0A1B0GTE0
ENSG00000175344ENST00000637350A0A1B0GU04
ENSG00000175344ENST00000637519A0A1B0GWH1
ENSG00000175344ENST00000637552A0A1B0GW47
ENSG00000175344ENST00000637786A0A1B0GU93
ENSG00000175344ENST00000637971A0A1B0GU11
ENSG00000175344ENST00000638031A0A1B0GVI5
ENSG00000175344ENST00000638081A0A1B0GUR5
ENSG00000175344ENST00000638106A0A1B0GV86

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Cholinergic synapseKEGGhsa04725
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Acetylcholine Binding And Downstream EventsREACTOMER-HSA-181431
Activation of Nicotinic Acetylcholine ReceptorsREACTOMER-HSA-629602
Postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-622327
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsREACTOMER-HSA-629594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443319Alzheimer DiseaseDiseaseClinicalAnnotationassociatedPD24951635
PA449394donepezilChemicalClinicalAnnotationassociatedPD24951635
PA449726galantamineChemicalClinicalAnnotationassociatedPD24951635
PA450626nicotineChemicalClinicalAnnotationassociatedPD20231857
PA451262rivastigmineChemicalClinicalAnnotationassociatedPD24951635

References

Pubmed IDYearTitleCitations
376409152024Regulation of Inflammation by IRAK-M Pathway Can Be Associated with nAchRalpha7 Activation and COVID-19.2
388360542024The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein.0
376409152024Regulation of Inflammation by IRAK-M Pathway Can Be Associated with nAchRalpha7 Activation and COVID-19.2
388360542024The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein.0
366047742023The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs.3
369669062023α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms.0
369726592023α7 Nicotinic acetylcholine receptors regulate translocation of HIF-1α to the cell nucleus and mitochondria upon hypoxia.0
369738132023α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect.7
372957702023Epstein-Barr virus downregulates the α7 nicotinic acetylcholine receptor of CD8(+) T lymphocytes might associate with coronary artery lesions in Kawasaki disease patients.0
378045922023Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.0
366047742023The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs.3
369669062023α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms.0
369726592023α7 Nicotinic acetylcholine receptors regulate translocation of HIF-1α to the cell nucleus and mitochondria upon hypoxia.0
369738132023α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect.7
372957702023Epstein-Barr virus downregulates the α7 nicotinic acetylcholine receptor of CD8(+) T lymphocytes might associate with coronary artery lesions in Kawasaki disease patients.0

Citation

Dessen P

CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45735/chrna7-(cholinergic-receptor-nicotinic-alpha-7-subunit)