NRG1 (neuregulin 1)

2007-02-01 Affiliation

Identity

HGNC

NRG1

LOCATION

8p12

LOCUSID

3084

ALIAS

ARIA,GGF,GGF2,HGL,HRG,HRG1,HRGA,MST131,MSTP131,NDF,NRG1-IT2,SMDF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3084
MIM: 142445
HGNC: 7997
Ensembl: ENSG00000157168

Variants:

dbSNP: 3084
ClinVar: 3084
TCGA: ENSG00000157168
COSMIC: NRG1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157168	ENST00000287842	Q02297
ENSG00000157168	ENST00000356819	Q02297
ENSG00000157168	ENST00000405005	Q02297
ENSG00000157168	ENST00000518084	E5RHQ1
ENSG00000157168	ENST00000518206	H0YCP0
ENSG00000157168	ENST00000519240	E5RIG8
ENSG00000157168	ENST00000519301	Q02297
ENSG00000157168	ENST00000520407	Q02297
ENSG00000157168	ENST00000520502	Q02297
ENSG00000157168	ENST00000521670	Q02297
ENSG00000157168	ENST00000522402	E5RHP6
ENSG00000157168	ENST00000523041	H0YDC2
ENSG00000157168	ENST00000523079	Q02297
ENSG00000157168	ENST00000523534	H0YBA3
ENSG00000157168	ENST00000539990	F6RJN6
ENSG00000157168	ENST00000614767	A0A087X0X9
ENSG00000157168	ENST00000650819	A0A494C1B5
ENSG00000157168	ENST00000650856	A0A494BZT4
ENSG00000157168	ENST00000650866	A0A494C1F5
ENSG00000157168	ENST00000650919	Q02297
ENSG00000157168	ENST00000650919	A0A024QY88
ENSG00000157168	ENST00000650967	A0A494C114
ENSG00000157168	ENST00000650980	A0A494C0K4
ENSG00000157168	ENST00000651149	A0A494C054
ENSG00000157168	ENST00000651333	A0A494C0L9
ENSG00000157168	ENST00000651335	A0A494C1G2
ENSG00000157168	ENST00000651696	A0A494C0T5
ENSG00000157168	ENST00000652588	A0A494C043
ENSG00000157168	ENST00000652592	A0A494C0Q4
ENSG00000157168	ENST00000652698	A0A494C1F8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ErbB signaling pathway	KEGG	ko04012
ErbB signaling pathway	KEGG	hsa04012
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Signaling by ERBB2	REACTOME	R-HSA-1227986
SHC1 events in ERBB2 signaling	REACTOME	R-HSA-1250196
GRB2 events in ERBB2 signaling	REACTOME	R-HSA-1963640
PI3K events in ERBB2 signaling	REACTOME	R-HSA-1963642
GRB7 events in ERBB2 signaling	REACTOME	R-HSA-1306955
Downregulation of ERBB2:ERBB3 signaling	REACTOME	R-HSA-1358803
Signaling by ERBB4	REACTOME	R-HSA-1236394
SHC1 events in ERBB4 signaling	REACTOME	R-HSA-1250347
PI3K events in ERBB4 signaling	REACTOME	R-HSA-1250342
Nuclear signaling by ERBB4	REACTOME	R-HSA-1251985
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
ERBB2 Regulates Cell Motility	REACTOME	R-HSA-6785631
ERBB2 Activates PTK6 Signaling	REACTOME	R-HSA-8847993
Signaling by PTK6	REACTOME	R-HSA-8848021
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
RET signaling	REACTOME	R-HSA-8853659
Downregulation of ERBB2 signaling	REACTOME	R-HSA-8863795

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA10040	cetuximab	Chemical	Pathway	associated
PA162373091	panitumumab	Chemical	Pathway	associated
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD
PA452233	antipsychotics	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
12145742	2002	Neuregulin 1 and susceptibility to schizophrenia.	456
18583979	2008	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	395
16767099	2006	Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia.	217
16618933	2006	Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease.	152
19736351	2009	Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.	151
12646923	2003	Segregation of receptor and ligand regulates activation of epithelial growth factor receptor.	136
16442083	2006	Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology.	136
12478479	2003	Association of neuregulin 1 with schizophrenia confirmed in a Scottish population.	131
12478479	2003	Association of neuregulin 1 with schizophrenia confirmed in a Scottish population.	131
18198266	2008	No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.	111

Citation

Dessen P

NRG1 (neuregulin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45743/nrg1-(neuregulin-1)