Identity
HGNC
LOCATION
17p13.3
LOCUSID
ALIAS
HPRP8,PRP8,PRPC8,RP13,SNRNP220
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10594
MIM: 607300
HGNC: 17340
Ensembl: ENSG00000174231
Variants:
dbSNP: 10594
ClinVar: 10594
TCGA: ENSG00000174231
COSMIC: PRPF8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38605034 | 2024 | PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. | 0 |
| 38605034 | 2024 | PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects. | 0 |
| 36609600 | 2023 | PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing. | 6 |
| 37357506 | 2023 | PRPF8 controls alternative splicing of PIRH2 to modulate the p53 pathway and survival of human ESCs. | 0 |
| 36609600 | 2023 | PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing. | 6 |
| 37357506 | 2023 | PRPF8 controls alternative splicing of PIRH2 to modulate the p53 pathway and survival of human ESCs. | 0 |
| 35124606 | 2022 | The role of splicing factor PRPF8 in breast cancer. | 2 |
| 35543142 | 2022 | Heterozygous variants in PRPF8 are associated with neurodevelopmental disorders. | 1 |
| 36322420 | 2022 | Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8. | 2 |
| 35124606 | 2022 | The role of splicing factor PRPF8 in breast cancer. | 2 |
| 35543142 | 2022 | Heterozygous variants in PRPF8 are associated with neurodevelopmental disorders. | 1 |
| 36322420 | 2022 | Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8. | 2 |
| 31815536 | 2020 | How Is Precursor Messenger RNA Spliced by the Spliceosome? | 40 |
| 31914407 | 2020 | The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. | 8 |
| 32690086 | 2020 | circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis. | 26 |
Citation
Dessen P
PRPF8 (pre-mRNA processing factor 8)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45748/prpf8-(pre-mrna-processing-factor-8)
