Identity
HGNC
LOCATION
21q22.13
LOCUSID
ALIAS
HMC13F06,HMC29C01,SIM,bHLHe15
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6493
MIM: 600892
HGNC: 10883
Ensembl: ENSG00000159263
Variants:
dbSNP: 6493
ClinVar: 6493
TCGA: ENSG00000159263
COSMIC: SIM2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000159263 | ENST00000290399 | Q14190 |
| ENSG00000159263 | ENST00000431229 | H7BZX8 |
| ENSG00000159263 | ENST00000483178 | V9GY04 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35730699 | 2022 | Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes. | 1 |
| 35730699 | 2022 | Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes. | 1 |
| 33650646 | 2021 | Long non‑coding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTO‑mediated demethylation. | 17 |
| 33650646 | 2021 | Long non‑coding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTO‑mediated demethylation. | 17 |
| 32124945 | 2020 | CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. | 6 |
| 32124945 | 2020 | CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. | 6 |
| 30531838 | 2019 | ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. | 9 |
| 31775907 | 2019 | Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress. | 2 |
| 31783895 | 2019 | Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer. | 6 |
| 30531838 | 2019 | ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition. | 9 |
| 31775907 | 2019 | Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress. | 2 |
| 31783895 | 2019 | Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer. | 6 |
| 29427302 | 2018 | Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications. | 14 |
| 29964097 | 2018 | Long noncoding RNA TMEM75 promotes colorectal cancer progression by activation of SIM2. | 2 |
| 29427302 | 2018 | Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications. | 14 |
Citation
Dessen P
SIM2 (SIM bHLH transcription factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45754/sim2-(sim-bhlh-transcription-factor-2)
