SIM2 (SIM bHLH transcription factor 2)

2007-02-01 Affiliation

Identity

HGNC

SIM2

LOCATION

21q22.13

LOCUSID

6493

ALIAS

HMC13F06,HMC29C01,SIM,bHLHe15

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6493
MIM: 600892
HGNC: 10883
Ensembl: ENSG00000159263

Variants:

dbSNP: 6493
ClinVar: 6493
TCGA: ENSG00000159263
COSMIC: SIM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159263	ENST00000290399	Q14190
ENSG00000159263	ENST00000431229	H7BZX8
ENSG00000159263	ENST00000483178	V9GY04

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35730699	2022	Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes.	1
35730699	2022	Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes.	1
33650646	2021	Long non‑coding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTO‑mediated demethylation.	17
33650646	2021	Long non‑coding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTO‑mediated demethylation.	17
32124945	2020	CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.	6
32124945	2020	CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer.	6
30531838	2019	ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.	9
31775907	2019	Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress.	2
31783895	2019	Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer.	6
30531838	2019	ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.	9
31775907	2019	Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress.	2
31783895	2019	Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer.	6
29427302	2018	Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications.	14
29964097	2018	Long noncoding RNA TMEM75 promotes colorectal cancer progression by activation of SIM2.	2
29427302	2018	Multiple roles of single-minded 2 in esophageal squamous cell carcinoma and its clinical implications.	14

Citation

Dessen P

SIM2 (SIM bHLH transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45754/sim2-(sim-bhlh-transcription-factor-2)