Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1906
MIM: 131240
HGNC: 3176
Ensembl: ENSG00000078401
Variants:
dbSNP: 1906
ClinVar: 1906
TCGA: ENSG00000078401
COSMIC: EDN1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000078401 | ENST00000379375 | P05305 |
| ENSG00000078401 | ENST00000379375 | Q6FH53 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA130232992 | bevacizumab | Chemical | ClinicalAnnotation | associated | PD | 27139155 | |
| PA162356187 | muraglitazar | Chemical | ClinicalAnnotation | associated | PD | 18794727 | |
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | 27139155 | |
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation | associated | PD | 18794727 | |
| PA443994 | Edema | Disease | ClinicalAnnotation | associated | PD | 18794727 | |
| PA444528 | Hyperlipidemias | Disease | ClinicalAnnotation | associated | PD | 18794727 | |
| PA447288 | Essential hypertension | Disease | ClinicalAnnotation | associated | PD | 15188945 | |
| PA448499 | atenolol | Chemical | ClinicalAnnotation | associated | PD | 15188945 | |
| PA450084 | irbesartan | Chemical | ClinicalAnnotation | associated | PD | 15188945 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38860875 | 2024 | Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein. | 0 |
| 38874661 | 2024 | Diagnostic potential of endothelin-1 in peri-implant diseases: a cross-sectional study. | 0 |
| 38884602 | 2024 | The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer. | 0 |
| 38860875 | 2024 | Microarray analysis demonstrates up-regulation of the endothelin-1 gene with compensatory down-regulation of the ETA receptor gene in human portal vein. | 0 |
| 38874661 | 2024 | Diagnostic potential of endothelin-1 in peri-implant diseases: a cross-sectional study. | 0 |
| 38884602 | 2024 | The endothelin-1-driven tumor-stroma feed-forward loops in high-grade serous ovarian cancer. | 0 |
| 36279697 | 2023 | Endothelin-1 gene polymorphism (G8002A) and endothelial monocyte-activating polypeptide II: Role in vascular dysfunction in pediatric patients with β-thalassemia major. | 0 |
| 36475746 | 2023 | Epstein-Barr Virus Regulates Endothelin-1 Expression through the ERK/FOXO1 Pathway in EBV-Associated Gastric Cancer. | 3 |
| 36675028 | 2023 | Endothelial Dysfunction Drives CRTd Outcome at 1-Year Follow-Up: A Novel Role as Biomarker for miR-130a-5p. | 1 |
| 36796652 | 2023 | Hypoxic glioma cell-secreted exosomal circ101491 promotes the progression of glioma by regulating miR-125b-5p/EDN1. | 5 |
| 36829141 | 2023 | Potential role of eNOS and EDN-1 gene polymorphisms in the development and progression of retinopathy of prematurity. | 0 |
| 36901906 | 2023 | Endothelin-1 Induces Cell Proliferation and Myofibroblast Differentiation through the ET(A)R/G(αq)/ERK Signaling Pathway in Human Cardiac Fibroblasts. | 4 |
| 36966225 | 2023 | Association of blood pressure variability with Endothelin-1 by menopause status among Black women: findings from the Jackson Heart Study. | 0 |
| 36977700 | 2023 | Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages. | 3 |
| 37036487 | 2023 | Plasma endothelin-1 may predict bevacizumab-induced proteinuria in patients with colorectal cancer. | 1 |
Citation
Dessen P
EDN1 (endothelin 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45765/edn1-(endothelin-1)
