AGT (angiotensinogen)

2007-02-01 Affiliation

Identity

HGNC

AGT

LOCATION

1q42.2

LOCUSID

183

ALIAS

ANHU,SERPINA8,hFLT1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 183
MIM: 106150
HGNC: 333
Ensembl: ENSG00000135744

Variants:

dbSNP: 183
ClinVar: 183
TCGA: ENSG00000135744
COSMIC: AGT

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135744	ENST00000366667	P01019
ENSG00000135744	ENST00000366667	B0ZBE2

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Renin-angiotensin system	KEGG	ko04614
Renin-angiotensin system	KEGG	hsa04614
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Metabolism of Angiotensinogen to Angiotensins	REACTOME	R-HSA-2022377
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164712308	Ace Inhibitors, Plain	Chemical	ClinicalAnnotation	associated	PD	14643574
PA164712462	Antiinflammatory agents, non-steroids	Chemical	ClinicalAnnotation	associated	PD	20538124
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PD	20538124
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated	PD	11849656
PA444552	Hypertension	Disease	ClinicalAnnotation	associated	PD	11593098, 14643574, 14700505, 15614026, 17261659, 25143324
PA446479	Hypertrophy, Left Ventricular	Disease	ClinicalAnnotation	associated	PD	11593098, 14700505, 15614026
PA448388	amlodipine	Chemical	ClinicalAnnotation	associated	PD
PA448497	aspirin	Chemical	ClinicalAnnotation	associated	PD	20824505
PA448499	atenolol	Chemical	ClinicalAnnotation	associated	PD	11593098, 14700505
PA448561	benazepril	Chemical	ClinicalAnnotation	associated	PD	17261659, 25143324
PA448970	chlorthalidone	Chemical	ClinicalAnnotation	associated	PD
PA450084	irbesartan	Chemical	ClinicalAnnotation	associated	PD	11593098, 14700505, 15614026
PA450242	lisinopril	Chemical	ClinicalAnnotation	associated	PD
PA451205	quinapril	Chemical	ClinicalAnnotation	associated	PD	11849656
PA452640	imidapril	Chemical	ClinicalAnnotation	associated	PD	25143324

References

Pubmed ID	Year	Title	Citations
19059306	2009	NADPH oxidases and angiotensin II receptor signaling.	115
15718497	2005	Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells.	100
12663475	2003	Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II.	99
17666408	2007	MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.	91
29351514	2018	The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7).	91
23488800	2013	ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis.	88
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19898482	2009	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	84
19075095	2009	Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients.	74
24694986	2014	Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rate.	70

Citation

Dessen P

AGT (angiotensinogen)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45772/agt-(angiotensinogen)