KHSRP (KH-type splicing regulatory protein)

2007-02-01  

Identity

HGNC
KHSRP
LOCATION
19p13.3
LOCUSID
8570
ALIAS
FBP2,FUBP2,KSRP,p75
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8570
MIM: 603445
HGNC: 6316
Ensembl: ENSG00000088247

Variants:

dbSNP: 8570
ClinVar: 8570
TCGA: ENSG00000088247
COSMIC: KHSRP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088247ENST00000398148Q92945
ENSG00000088247ENST00000594496M0R263
ENSG00000088247ENST00000594745M0QYG1
ENSG00000088247ENST00000595223M0R3J3
ENSG00000088247ENST00000595258M0QXW7
ENSG00000088247ENST00000595548M0QYH3
ENSG00000088247ENST00000597656M0R251
ENSG00000088247ENST00000599395M0R0I5
ENSG00000088247ENST00000600480M0R0C6
ENSG00000088247ENST00000619396A0A087WTP3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Gene ExpressionREACTOMER-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375641982023Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.4
375807572023The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.4
375641982023Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.4
375807572023The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.4
326730632021Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis.2
326730632021Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis.2
313132862020Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.11
313132862020Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.11
305782892019The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.9
312694602019KSRP modulates melanoma growth and efficacy of vemurafenib.7
314045412019KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment.6
315118262019The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4(+) T Cells.9
317758882019RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.43
305782892019The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.9
312694602019KSRP modulates melanoma growth and efficacy of vemurafenib.7

Citation

Dessen P

KHSRP (KH-type splicing regulatory protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45774