KHSRP (KH-type splicing regulatory protein)

2007-02-01 Affiliation

Identity

HGNC

KHSRP

LOCATION

19p13.3

LOCUSID

8570

ALIAS

FBP2,FUBP2,KSRP,p75

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8570
MIM: 603445
HGNC: 6316
Ensembl: ENSG00000088247

Variants:

dbSNP: 8570
ClinVar: 8570
TCGA: ENSG00000088247
COSMIC: KHSRP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000088247	ENST00000398148	Q92945
ENSG00000088247	ENST00000594496	M0R263
ENSG00000088247	ENST00000594745	M0QYG1
ENSG00000088247	ENST00000595223	M0R3J3
ENSG00000088247	ENST00000595258	M0QXW7
ENSG00000088247	ENST00000595548	M0QYH3
ENSG00000088247	ENST00000597656	M0R251
ENSG00000088247	ENST00000599395	M0R0I5
ENSG00000088247	ENST00000600480	M0R0C6
ENSG00000088247	ENST00000619396	A0A087WTP3

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
PERK regulates gene expression	REACTOME	R-HSA-381042
ATF4 activates genes	REACTOME	R-HSA-380994
Gene Expression	REACTOME	R-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elements	REACTOME	R-HSA-450531
KSRP (KHSRP) binds and destabilizes mRNA	REACTOME	R-HSA-450604

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37564198	2023	Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.	4
37580757	2023	The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.	4
37564198	2023	Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.	4
37580757	2023	The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.	4
32673063	2021	Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis.	2
32673063	2021	Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis.	2
31313286	2020	Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.	11
31313286	2020	Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.	11
30578289	2019	The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.	9
31269460	2019	KSRP modulates melanoma growth and efficacy of vemurafenib.	7
31404541	2019	KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment.	6
31511826	2019	The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4(+) T Cells.	9
31775888	2019	RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.	43
30578289	2019	The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.	9
31269460	2019	KSRP modulates melanoma growth and efficacy of vemurafenib.	7

Citation

Dessen P

KHSRP (KH-type splicing regulatory protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45774/khsrp-(kh-type-splicing-regulatory-protein)