CD6 (CD6 molecule)

2007-02-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
TP120

Other Information

Locus ID:

NCBI: 923
MIM: 186720
HGNC: 1691
Ensembl: ENSG00000013725

Variants:

dbSNP: 923
ClinVar: 923
TCGA: ENSG00000013725
COSMIC: CD6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000013725ENST00000313421P30203
ENSG00000013725ENST00000344931G5E973
ENSG00000013725ENST00000352009P30203
ENSG00000013725ENST00000433107E7ER04
ENSG00000013725ENST00000452451P30203
ENSG00000013725ENST00000538611H0YGL3
ENSG00000013725ENST00000542157F6UFK6
ENSG00000013725ENST00000542254F5H835

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195259532009Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.291
195259532009Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.291
124937732003Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.152
198791942009Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.80
169147522006CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76.44
198651022010Multiple sclerosis susceptibility alleles in African Americans.35
176017772007CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
218496852011The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.26
219566092012CD6 attenuates early and late signaling events, setting thresholds for T-cell activation.25

Citation

Dessen P

CD6 (CD6 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45784/cd6-(cd6-molecule)