CD6 (CD6 molecule)

2007-02-01  

Identity

HGNC
CD6
LOCATION
11q12.2
LOCUSID
923
ALIAS
TP120

Other Information

Locus ID:

NCBI: 923
MIM: 186720
HGNC: 1691
Ensembl: ENSG00000013725

Variants:

dbSNP: 923
ClinVar: 923
TCGA: ENSG00000013725
COSMIC: CD6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000013725ENST00000313421P30203
ENSG00000013725ENST00000344931G5E973
ENSG00000013725ENST00000352009P30203
ENSG00000013725ENST00000433107E7ER04
ENSG00000013725ENST00000452451P30203
ENSG00000013725ENST00000538611H0YGL3
ENSG00000013725ENST00000542157F6UFK6
ENSG00000013725ENST00000542254F5H835

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382800672024Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells.0
382800672024Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells.0
381393402023CD6 and Its Interacting Partners: Newcomers to the Block of Cancer Immunotherapies.0
381393402023CD6 and Its Interacting Partners: Newcomers to the Block of Cancer Immunotherapies.0
349817752022The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses.20
354874542022Th1 and Th17 cells are resistant towards T cell activation-induced downregulation of CD6.4
357673662022Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.2
349817752022The CD6/ALCAM pathway promotes lupus nephritis via T cell-mediated responses.20
354874542022Th1 and Th17 cells are resistant towards T cell activation-induced downregulation of CD6.4
357673662022Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.2
339133832021Compromised levels of CD6 and reduced T cell activation in the aged immune system.3
340701592021Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6.5
339133832021Compromised levels of CD6 and reduced T cell activation in the aged immune system.3
340701592021Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6.5
323079072020Attenuation of Murine Collagen-Induced Arthritis by Targeting CD6.14

Citation

Dessen P

CD6 (CD6 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45784/cd6-(cd6-molecule)